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Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts

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Title: Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts
Authors: Oami, Takehiko Browse this author →KAKEN DB
Karasawa, Satoshi Browse this author →KAKEN DB
Shimada, Tadanaga Browse this author →KAKEN DB
Nakada, Taka-aki Browse this author →KAKEN DB
Abe, Toshikazu Browse this author →KAKEN DB
Ogura, Hiroshi Browse this author →KAKEN DB
Shiraishi, Atsushi Browse this author →KAKEN DB
Kushimoto, Shigeki Browse this author →KAKEN DB
Saitoh, Daizoh Browse this author →KAKEN DB
Fujishima, Seitaro Browse this author →KAKEN DB
Mayumi, Toshihiko Browse this author →KAKEN DB
Shiino, Yasukazu Browse this author
Tarui, Takehiko Browse this author
Hifumi, Toru Browse this author →KAKEN DB
Otomo, Yasuhiro Browse this author →KAKEN DB
Okamoto, Kohji Browse this author
Umemura, Yutaka Browse this author →KAKEN DB
Kotani, Joji Browse this author →KAKEN DB
Sakamoto, Yuichiro Browse this author →KAKEN DB
Sasaki, Junichi Browse this author →KAKEN DB
Shiraishi, Shin-ichiro Browse this author →KAKEN DB
Takuma, Kiyotsugu Browse this author →KAKEN DB
Tsuruta, Ryosuke Browse this author →KAKEN DB
Hagiwara, Akiyoshi Browse this author
Yamakawa, Kazuma Browse this author →KAKEN DB
Masuno, Tomohiko Browse this author →KAKEN DB
Takeyama, Naoshi Browse this author →KAKEN DB
Yamashita, Norio Browse this author
Ikeda, Hiroto Browse this author
Ueyama, Masashi Browse this author
Fujimi, Satoshi Browse this author
Gando, Satoshi Browse this author →KAKEN DB
Issue Date: 15-Jan-2021
Publisher: Nature Research
Journal Title: Scientific reports
Volume: 11
Issue: 1
Start Page: 1615
Publisher DOI: 10.1038/s41598-020-80284-3
Abstract: Current research regarding the association between body mass index (BMI) and altered clinical outcomes of sepsis in Asian populations is insufficient. We investigated the association between BMI and clinical outcomes using two Japanese cohorts of severe sepsis (derivation cohort, Chiba University Hospital, n=614; validation cohort, multicenter cohort, n=1561). Participants were categorized into the underweight (BMI<18.5) and non-underweight (BMI<greater than or equal to>18.5) groups. The primary outcome was 28-day mortality. Univariate analysis of the derivation cohort indicated increased 28-day mortality trend in the underweight group compared to the non-underweight group (underweight 24.4% [20/82 cases] vs. non-underweight 16.0% [85/532 cases]; p=0.060). In the primary analysis, multivariate analysis adjusted for baseline imbalance revealed that patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p=0.031, adjusted odds ratio [OR] 1.91, 95% confidence interval [CI] 1.06-3.46). In a repeated analysis using a multicenter validation cohort (underweight n=343, non-underweight n=1218), patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p=0.045, OR 1.40, 95% CI 1.00-1.97). In conclusion, patients with a BMI<18.5 had a significantly increased 28-day mortality compared to those with a BMI<greater than or equal to>18.5 in Japanese cohorts with severe sepsis.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/80526
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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