Title: | Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts |
Authors: | Oami, Takehiko Browse this author →KAKEN DB |
Karasawa, Satoshi Browse this author →KAKEN DB |
Shimada, Tadanaga Browse this author →KAKEN DB |
Nakada, Taka-aki Browse this author →KAKEN DB |
Abe, Toshikazu Browse this author →KAKEN DB |
Ogura, Hiroshi Browse this author →KAKEN DB |
Shiraishi, Atsushi Browse this author →KAKEN DB |
Kushimoto, Shigeki Browse this author →KAKEN DB |
Saitoh, Daizoh Browse this author →KAKEN DB |
Fujishima, Seitaro Browse this author →KAKEN DB |
Mayumi, Toshihiko Browse this author →KAKEN DB |
Shiino, Yasukazu Browse this author |
Tarui, Takehiko Browse this author |
Hifumi, Toru Browse this author →KAKEN DB |
Otomo, Yasuhiro Browse this author →KAKEN DB |
Okamoto, Kohji Browse this author |
Umemura, Yutaka Browse this author →KAKEN DB |
Kotani, Joji Browse this author →KAKEN DB |
Sakamoto, Yuichiro Browse this author →KAKEN DB |
Sasaki, Junichi Browse this author →KAKEN DB |
Shiraishi, Shin-ichiro Browse this author →KAKEN DB |
Takuma, Kiyotsugu Browse this author →KAKEN DB |
Tsuruta, Ryosuke Browse this author →KAKEN DB |
Hagiwara, Akiyoshi Browse this author |
Yamakawa, Kazuma Browse this author →KAKEN DB |
Masuno, Tomohiko Browse this author →KAKEN DB |
Takeyama, Naoshi Browse this author →KAKEN DB |
Yamashita, Norio Browse this author |
Ikeda, Hiroto Browse this author |
Ueyama, Masashi Browse this author |
Fujimi, Satoshi Browse this author |
Gando, Satoshi Browse this author →KAKEN DB |
Issue Date: | 15-Jan-2021 |
Publisher: | Nature Research |
Journal Title: | Scientific reports |
Volume: | 11 |
Issue: | 1 |
Start Page: | 1615 |
Publisher DOI: | 10.1038/s41598-020-80284-3 |
Abstract: | Current research regarding the association between body mass index (BMI) and altered clinical outcomes of sepsis in Asian populations is insufficient. We investigated the association between BMI and clinical outcomes using two Japanese cohorts of severe sepsis (derivation cohort, Chiba University Hospital, n=614; validation cohort, multicenter cohort, n=1561). Participants were categorized into the underweight (BMI<18.5) and non-underweight (BMI<greater than or equal to>18.5) groups. The primary outcome was 28-day mortality. Univariate analysis of the derivation cohort indicated increased 28-day mortality trend in the underweight group compared to the non-underweight group (underweight 24.4% [20/82 cases] vs. non-underweight 16.0% [85/532 cases]; p=0.060). In the primary analysis, multivariate analysis adjusted for baseline imbalance revealed that patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p=0.031, adjusted odds ratio [OR] 1.91, 95% confidence interval [CI] 1.06-3.46). In a repeated analysis using a multicenter validation cohort (underweight n=343, non-underweight n=1218), patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p=0.045, OR 1.40, 95% CI 1.00-1.97). In conclusion, patients with a BMI<18.5 had a significantly increased 28-day mortality compared to those with a BMI<greater than or equal to>18.5 in Japanese cohorts with severe sepsis. |
Rights: | http://creativecommons.org/licenses/by/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/80526 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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