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Silychristin derivatives conjugated with coniferylalcohols from silymarin and their pancreatic α-amylase inhibitory activity

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Title: Silychristin derivatives conjugated with coniferylalcohols from silymarin and their pancreatic α-amylase inhibitory activity
Authors: Kato, Eisuke Browse this author →KAKEN DB
Kushibiki, Natsuka Browse this author
Satoh, Hiroshi Browse this author
Kawabata, Jun Browse this author →KAKEN DB
Keywords: diabetes mellitus
milk thistle
Issue Date: 18-Mar-2020
Publisher: Taylor & Francis
Journal Title: Natural Product Research
Volume: 34
Issue: 6
Start Page: 759
End Page: 765
Publisher DOI: 10.1080/14786419.2018.1499639
PMID: 30445852
Abstract: Silymarin is a mixture of flavonolignans extracted from the fruit of Silybum marianum (milk thistle). The latter is used as a medicinal plant to treat liver and gallbladder disorders. Recently, silymarin has been investigated for its effects against diabetes mellitus, and shown to reduce serum levels of glucose in model animals and in clinical trials. This effect can be explained mainly by the protective effect of silymarin against pancreatic beta-cells, but the involvement of other mechanisms is possible. We demonstrated the α-amylase inhibitory activity of silymarin and investigated the components responsible for this effect. Two major flavonolignans, silibinin and silychristin, did not show inhibition against α-amylase, but two novel silychristin derivatives conjugated with dehydrodiconiferyl alcohol were isolated as the mildly inhibiting components of silymarin. Further analyses indicated the presence of various silychristin derivatives in silymarin that may act synergistically to show α-amylase inhibitory activity.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Natural Product Research on Mar.18.2020, available online:
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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