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Post-translational Wnt receptor regulation : Is the fog slowly clearing?

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Title: Post-translational Wnt receptor regulation : Is the fog slowly clearing?
Authors: Tsukiyama, Tadasuke Browse this author →KAKEN DB
Koo, Bon-Kyoung Browse this author
Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords: CRCs
Wnt signaling
Issue Date: Apr-2021
Publisher: John Wiley & Sons
Journal Title: Bioessays
Volume: 43
Issue: 4
Start Page: e2000297
Publisher DOI: 10.1002/bies.202000297
Abstract: Wnt signaling plays pivotal roles during our entire lives, from conception to death, through the regulation of morphogenesis in developing embryos and the maintenance of tissue homeostasis in adults. The regulation of Wnt signaling occurs on several levels: at the receptor level on the plasma membrane, at the beta-catenin protein level in the cytoplasm, and through transcriptional regulation in the nucleus. Several recent studies have focused on the mechanisms of Wnt receptor regulation, following the discovery that the Wnt receptor frizzled (Fzd) is a target of the ubiquitin ligases, RNF43 and ZNRF3. RNF43 and ZNRF3 are homologous genes that are mutated in several cancers. The details underlying their mechanism of action continue to unfold, while at the same time raising many new questions. In this review, we discuss advances and controversies in our understanding of Wnt receptor regulation.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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