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Association of inflammatory biomarkers with long-term outcomes after curative surgery for mass-forming intrahepatic cholangiocarcinoma

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Title: Association of inflammatory biomarkers with long-term outcomes after curative surgery for mass-forming intrahepatic cholangiocarcinoma
Authors: Ohira, Masafumi Browse this author
Yoshizumi, Tomoharu Browse this author →KAKEN DB
Yugawa, Kyohei Browse this author
Kosai-Fujimoto, Yukiko Browse this author
Inokuchi, Shoichi Browse this author
Motomura, Takashi Browse this author →KAKEN DB
Mano, Yohei Browse this author
Toshima, Takeo Browse this author →KAKEN DB
Itoh, Shinji Browse this author →KAKEN DB
Harada, Noboru Browse this author →KAKEN DB
Ikegami, Toru Browse this author →KAKEN DB
Soejima, Yuji Browse this author
Taketomi, Akinobu Browse this author →KAKEN DB
Mori, Masaki Browse this author →KAKEN DB
Keywords: Inflammatory biomarker
Intrahepatic cholangiocarcinoma
Long-term outcome
Issue Date: Apr-2020
Publisher: Springer
Journal Title: Surgery today
Volume: 50
Issue: 4
Start Page: 379
End Page: 388
Publisher DOI: 10.1007/s00595-019-01905-7
Abstract: Purpose Inflammatory biomarkers such as the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are reportedly predictive of the long-term outcomes of several cancers. We evaluated their correlations with the post-surgical long-term outcomes of patients with mass-forming (MF) intrahepatic cholangiocarcinoma (ICC). Methods The subjects of this study were 52 patients who underwent hepatic resection for MF-ICC at our hospital. We measured the cutoff values of NLR, LMR and PLR, using receiver operating characteristic curves, and compared the survival rates of patients with high vs. those with low values. We also evaluated a prognostic scoring system based on significant inflammatory biomarkers. Results The cutoff values for NLR, LMR, and PLR were 1.93, 4.78, and 98, respectively. The high-NLR and low-LMR groups had significantly worse prognoses than the low-NLR and high-LMR groups. We designed a scoring system using the inflammation score (IS) based on NLR and LMR values, stratifying patients into three groups with scores of 0, 1, or 2. The IS was significantly correlated with overall survival (OS), with 5-year survival rates by the IS score of 100% for 0, 61% for 1, and 32% for 2 (P = 0.011). The IS was found to be an independent predictor of OS in multivariate analysis. Conclusions Our IS scoring system may predict long-term outcomes after surgery for MF-ICC.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大平 将史

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