| Title: | Association of inflammatory biomarkers with long-term outcomes after curative surgery for mass-forming intrahepatic cholangiocarcinoma |
| Authors: | Ohira, Masafumi Browse this author |
| Yoshizumi, Tomoharu Browse this author →KAKEN DB |
| Yugawa, Kyohei Browse this author |
| Kosai-Fujimoto, Yukiko Browse this author |
| Inokuchi, Shoichi Browse this author |
| Motomura, Takashi Browse this author →KAKEN DB |
| Mano, Yohei Browse this author |
| Toshima, Takeo Browse this author →KAKEN DB |
| Itoh, Shinji Browse this author →KAKEN DB |
| Harada, Noboru Browse this author →KAKEN DB |
| Ikegami, Toru Browse this author →KAKEN DB |
| Soejima, Yuji Browse this author |
| Taketomi, Akinobu Browse this author →KAKEN DB |
| Mori, Masaki Browse this author →KAKEN DB |
| Keywords: | Inflammatory biomarker |
| Intrahepatic cholangiocarcinoma |
| Long-term outcome |
| Issue Date: | Apr-2020 |
| Publisher: | Springer |
| Journal Title: | Surgery today |
| Volume: | 50 |
| Issue: | 4 |
| Start Page: | 379 |
| End Page: | 388 |
| Publisher DOI: | 10.1007/s00595-019-01905-7 |
| Abstract: | Purpose Inflammatory biomarkers such as the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are reportedly predictive of the long-term outcomes of several cancers. We evaluated their correlations with the post-surgical long-term outcomes of patients with mass-forming (MF) intrahepatic cholangiocarcinoma (ICC). Methods The subjects of this study were 52 patients who underwent hepatic resection for MF-ICC at our hospital. We measured the cutoff values of NLR, LMR and PLR, using receiver operating characteristic curves, and compared the survival rates of patients with high vs. those with low values. We also evaluated a prognostic scoring system based on significant inflammatory biomarkers. Results The cutoff values for NLR, LMR, and PLR were 1.93, 4.78, and 98, respectively. The high-NLR and low-LMR groups had significantly worse prognoses than the low-NLR and high-LMR groups. We designed a scoring system using the inflammation score (IS) based on NLR and LMR values, stratifying patients into three groups with scores of 0, 1, or 2. The IS was significantly correlated with overall survival (OS), with 5-year survival rates by the IS score of 100% for 0, 61% for 1, and 32% for 2 (P = 0.011). The IS was found to be an independent predictor of OS in multivariate analysis. Conclusions Our IS scoring system may predict long-term outcomes after surgery for MF-ICC. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-019-01905-7 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/80858 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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