|
Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >
Glucose metabolism disorders in children with refractory nephrotic syndrome
| Title: | Glucose metabolism disorders in children with refractory nephrotic syndrome |
| Authors: | Takahashi, Toshiyuki Browse this author | | Okamoto, Takayuki Browse this author →KAKEN DB | | Sato, Yasuyuki Browse this author | | Hayashi, Asako Browse this author | | Ueda, Yasuhiro Browse this author | | Ariga, Tadashi Browse this author →KAKEN DB |
| Keywords: | Glucose metabolism disorders | | Oral glucose tolerance test | | Nephrotic syndrome | | Glucocorticoids | | Calcineurin inhibitors |
| Issue Date: | Apr-2020 |
| Publisher: | Springer |
| Journal Title: | Pediatric nephrology |
| Volume: | 35 |
| Start Page: | 649 |
| End Page: | 657 |
| Publisher DOI: | 10.1007/s00467-019-04360-1 |
| Abstract: | Background Patients with refractory nephrotic syndrome (NS) are at high risk of medication-induced glucose metabolism disorders, because of their long-term use of diabetogenic medications, particularly glucocorticoids and calcineurin inhibitors (CNIs). However, there have been no comprehensive evaluations of glucose metabolism disorders in pediatric patients with refractory NS. Moreover, glucocorticoids and CNIs could not be discontinued in these patients until the effectiveness of rituximab on refractory NS was shown, and therefore, there has been limited opportunity to evaluate glucose metabolism disorders after discontinuation of these medications. Methods Consecutive pediatric patients who started rituximab treatment for refractory NS were enrolled. Their glucose metabolism conditions were evaluated using the oral glucose tolerance tests (OGTT) and HbA1c levels at the initiation of rituximab treatment. Patients with glucose metabolism disorders at the first evaluation were reevaluated after approximately 2 years. Results Overall, 57% (20/35) of study patients had glucose metabolism disorders, and 40% (8/20) of these patients were detected only by their 2-h OGTT blood glucose levels and not by their fasting blood glucose or HbA1c levels. Non-obese/non-overweight patients had significantly more glucose metabolism disorders than obese/overweight patients (p = 0.019). In addition, glucose metabolism disorders in 71% (10/14) of patients persisted after the discontinuation of glucocorticoids and CNIs. Conclusions Whether the patient is obese/overweight or not, patients with refractory NS are at high risk of developing glucose metabolism disorders, even in childhood. Non-obese/non-overweight patients who are at high risk of diabetes need extra vigilance. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in Pediatric Nephrology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00467-019-04360-1 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/80861 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 岡本 孝之
|
