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Current practice and effects of intravenous anticoagulant therapy in hospitalized acute heart failure patients with sinus rhythm
| Title: | Current practice and effects of intravenous anticoagulant therapy in hospitalized acute heart failure patients with sinus rhythm |
| Authors: | Nakano, Hiroki Browse this author | | Hamatani, Yasuhiro Browse this author | | Nagai, Toshiyuki Browse this author →KAKEN DB | | Nakai, Michikazu Browse this author | | Nishimura, Kunihiro Browse this author | | Sumita, Yoko Browse this author | | Ogawa, Hisao Browse this author | | Anzai, Toshihisa Browse this author |
| Issue Date: | 13-Jan-2021 |
| Publisher: | Nature Research |
| Journal Title: | Scientific reports |
| Volume: | 11 |
| Start Page: | 1202 |
| Publisher DOI: | 10.1038/s41598-020-79700-5 |
| PMID: | 33441666 |
| Abstract: | Although the risk of thromboembolism is increased in heart failure (HF) patients irrespective of atrial fibrillation (AF), especially during the acute decompensated phase, the effects of intravenous anticoagulants for these patients remain unclear. We sought to investigate the current practice and effects of intravenous anticoagulant therapy in acute HF (AHF) patients with sinus rhythm. We analyzed a nationwide prospective cohort from April 2012 to March 2016. We extracted 309,015 AHF adult patients. After application of the exclusion criteria, we divided the 92,573 study population into non-heparin [n=70,621 (76.3%)] and heparin [n=21,952 (23.7%)] groups according to the use of intravenous heparin for the first 2 consecutive days after admission. Multivariable logistic regression analyses demonstrated that heparin administration was not associated with in-hospital mortality (OR 0.97, 95% CI 0.91-1.03) and intracranial hemorrhage (OR 1.18, 95% CI 0.78-1.77), while heparin administration was significantly associated with increased incidence of ischemic stroke (OR 1.49, 95% CI 1.29-1.72) and venous thromboembolism (OR 1.62, 95% CI 1.14-2.30). In conclusion, intravenous heparin administration was not associated with favorable in-hospital outcomes in AHF patients with sinus rhythm. Routine additive use of intravenous heparin to initial treatment might not be recommended in AHF patients. |
| Publisher URI: | https://doi.org/10.1038/s41598-020-79700-5 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81044 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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