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Factors based on optical coherence tomography correlated with vision impairment in diabetic patients

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Title: Factors based on optical coherence tomography correlated with vision impairment in diabetic patients
Authors: Endo, Hiroaki Browse this author
Kase, Satoru Browse this author →KAKEN DB
Tanaka, Hikari Browse this author
Takahashi, Mitsuo Browse this author
Katsuta, Satoshi Browse this author
Suzuki, Yasuo Browse this author
Fujii, Minako Browse this author
Ishida, Susumu Browse this author
Kase, Manabu Browse this author
Issue Date: 4-Feb-2021
Publisher: Nature Research
Journal Title: Scientific reports
Volume: 11
Issue: 1
Start Page: 3004
Publisher DOI: 10.1038/s41598-021-82334-w
PMID: 33542264
Abstract: The aim of this study is to evaluate the relationship between retinal structures and visual acuity in diabetic patients using optical coherence tomography (OCT) and OCT angiography (OCTA). This study was a retrospective observational study conducted at a single medical center in Japan. Evaluation of retinal images was analyzed using spectral domain OCT. Twelve factors including central retinal thickness, length of disorganization of retinal inner layer (DRIL), number of inner hyperreflective foci, number of outer hyperreflective foci, height of intraretinal fluid, height of subretinal fluid, length of external limiting membrane disruption, length of external ellipsoid zone (EZ) disruption, vessel density of superficial capillary plexus (SCP), foveal avascular zone (FAZ) area, and FAZ circularity were analyzed based on OCT/OCTA findings. Multivariate analysis was used to investigate the OCT-based factors that could be correlated with poor visual acuity in treatment-naive diabetic eyes. A total of 183 eyes of 123 diabetic patients with type 2 diabetes (mean age 61.9 +/- 12.3 years, 66 men and 57 women) and 62 eyes of 55 control subjects (mean age 64.4 +/- 12.5 years, 15 men and 40 women) was enrolled in this study. Multiple regression analysis showed that OCT-based factors correlated with visual acuity were length of DRIL (beta =0.24, P<0.01), length of EZ disruption (<beta>=0.35, P<0.001), and FAZ circularity (<beta>=-0.14, P<0.05). The other factors showed no significant correlation. In conclusion, the length of DRIL, length of EZ disruption, and FAZ circularity measured by OCT were identified as related factors for visual impairment in treatment-naive diabetic eyes.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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