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Evaluation of the ameliorative effect of Spirulina (Arthrospira platensis) supplementation on parameters relating to lead poisoning and obesity in C57BL/6J mice
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| Title: | Evaluation of the ameliorative effect of Spirulina (Arthrospira platensis) supplementation on parameters relating to lead poisoning and obesity in C57BL/6J mice |
| Authors: | Nakata, Hokuto Browse this author →KAKEN DB | | Nakayama, Shouta M. M. Browse this author →KAKEN DB | | Kataba, Andrew Browse this author | | Yohannes, Yared Beyene Browse this author | | Ikenaka, Yoshinori Browse this author →KAKEN DB | | Ishizuka, Mayumi Browse this author →KAKEN DB |
| Keywords: | Lead poisoning | | Obesity prevention | | Spirulina | | Cost-effective | | C57BL/6J |
| Issue Date: | Feb-2021 |
| Publisher: | Elsevier |
| Journal Title: | Journal of functional foods |
| Volume: | 77 |
| Start Page: | 104344 |
| Publisher DOI: | 10.1016/j.jff.2020.104344 |
| Abstract: | The current study aimed to validate the possible ameliorative effects of Spirulina (Arthrospira platensis) on lead poisoning and obesity using C57BL/6J mice. After a treatment period, we performed metal analyses, as well as hematocrit and plasma biochemical parameter measurements, and assayed oxidative stress markers and erythrocyte 6-aminolevulinic acid dehydratase (ALAD) activity. Our results highlighted the effectiveness of Spirulina in improving anemia status with the normalization of hematocrit levels and ALAD activity ratios, even in mice that exhibited obesity in addition to lead poisoning. Spirulina treatment also decreased epididymal white adipose tissue weight and increased plasma high-density lipoprotein levels, which are normally reduced after lead exposure. However, most of the studied plasma biochemical parameters and oxidative stress markers did not show large changes after treatment, likely because of the short duration of treatment. Further studies with longer-term exposures are required to validate the usefulness of Spirulina suggested in the present study. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81070 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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