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Hokkaido University Collection of Scholarly and Academic Papers >
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Mild thrombocytopenia indicating maternal organ damage in pre-eclampsia: a cross-sectional study
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Mild thrombocytopenia indicating maternal organ damage in pre-eclampsia: a cross-sectional study |
| Authors: | Mayama, Michinori Browse this author | | Morikawa, Mamoru Browse this author | | Yamada, Takashi Browse this author | | Umazume, Takeshi Browse this author | | Noshiro, Kiwamu Browse this author | | Nakagawa, Kinuko Browse this author | | Saito, Yoshihiro Browse this author | | Chiba, Kentaro Browse this author | | Kawaguchi, Satoshi Browse this author | | Watari, Hidemichi Browse this author →KAKEN DB |
| Keywords: | Cut-off value | | Maternal organ damage | | Pre-eclampsia | | Preterm delivery | | Thrombocytopenia |
| Issue Date: | 28-Jan-2021 |
| Publisher: | BioMed Central |
| Journal Title: | BMC pregnancy and childbirth |
| Volume: | 21 |
| Issue: | 1 |
| Start Page: | 91 |
| Publisher DOI: | 10.1186/s12884-021-03564-4 |
| PMID: | 33509105 |
| Abstract: | BackgroundCurrently, there is a disagreement between guidelines regarding platelet count cut-off values as a sign of maternal organ damage in pre-eclampsia; the American College of Obstetricians and Gynecologists guidelines state a cut-off value of <100x10(9)/L; however, the International Society for the Study of Hypertension in Pregnancy guidelines specify a cut-off of <150x10(9)/L. We evaluated the effect of mild thrombocytopenia: platelet count<150x10(9)/L and <greater than or equal to>100x10(9)/L on clinical features of pre-eclampsia to examine whether mild thrombocytopenia reflects maternal organ damage in pre-eclampsia.MethodsA total of 264 women were enrolled in this study. Participants were divided into three groups based on platelet count levels at delivery: normal, >= 150x10(9)/L; mild thrombocytopenia, <150x10(9)/L and <greater than or equal to>100x10(9)/L; and severe thrombocytopenia, <100x10(9)/L. Risk of severe hypertension, utero-placental dysfunction, maternal organ damage, preterm delivery, and neonatal intensive care unit admission were analyzed based on platelet count levels. Estimated relative risk was calculated with a Poisson regression analysis with a robust error.ResultsPlatelet counts indicated normal levels in 189 patients, mild thrombocytopenia in 51 patients, and severe thrombocytopenia in 24 patients. The estimated relative risks of severe thrombocytopenia were 4.46 [95% confidence interval, 2.59-7.68] for maternal organ damage except for thrombocytopenia, 1.61 [1.06-2.45] for preterm delivery<34 gestational weeks, and 1.35 [1.06-1.73] for neonatal intensive care unit admission. On the other hand, the estimated relative risks of mild thrombocytopenia were 0.97 [0.41-2.26] for maternal organ damage except for thrombocytopenia, 0.91 [0.62-1.35] for preterm delivery<34 gestational weeks, and 0.97 [0.76-1.24] for neonatal intensive care unit admission.ConclusionsMild thrombocytopenia was not associated with severe features of pre-eclampsia and would not be suitable as a sign of maternal organ damage. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81074 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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