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Combination of alcohol and glucose consumption as a risk to induce reactive hypoglycemia

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Title: Combination of alcohol and glucose consumption as a risk to induce reactive hypoglycemia
Authors: Oba‐Yamamoto, Chiho Browse this author
Takeuchi, Jun Browse this author
Nakamura, Akinobu Browse this author →KAKEN DB
Takikawa, Ryoko Browse this author
Ozaki, Ayano Browse this author
Nomoto, Hiroshi Browse this author →KAKEN DB
Kameda, Hiraku Browse this author →KAKEN DB
Cho, Kyu Yong Browse this author
Atsumi, Tatsuya Browse this author →KAKEN DB
Miyoshi, Hideaki Browse this author →KAKEN DB
Keywords: Alcohol
Oral glucosetolerance test
Issue Date: Apr-2021
Journal Title: Journal of Diabetes Investigation
Volume: 12
Issue: 4
Start Page: 651
End Page: 657
Publisher DOI: 10.1111/jdi.13375
Abstract: Aims/Introduction Alcohol consumption has been reported to cause hypoglycemia. However, the mechanism involved has not been unequivocally established. This study comprised healthy volunteers. We carried out a prospective trial to compare the effects of glucose and alcohol consumption, alone or in combination, on glucose and lipid metabolism. Materials and Methods A 75‐g oral glucose tolerance test (OGTT), a combined 75‐g glucose plus 20‐g alcohol tolerance test (OGATT) and a 20‐g alcohol tolerance test (OATT) were carried out in the participants. Plasma glucose, insulin, triglyceride and ethanol concentrations during each test were compared. Results We studied 10 participants. Their plasma glucose concentrations 15 and 30 min after the intake of 75 g of glucose were significantly higher during the OGATT than the OGTT. Hypoglycemia occurred in five participants after the OGATT, which was significantly more frequently than after the OGTT (P = 0.046). Hypoglycemia did not occur after the OATT, and the ethanol concentration was significantly lower after the OGATT than the OATT. The changes in triglyceride concentration from 30 min after the consumption of 75 g of glucose were significantly greater during the OGATT than the OGTT. The plasma insulin concentrations peaked after 60 min during both the OGTT and OGATT, and were significantly higher during the OGATT (P = 0.047). There were no differences between the two interventions in the Matsuda or disposition indexes. Conclusions Hypoglycemia occurred more frequently after the simultaneous consumption of alcohol plus glucose than after the consumption of glucose alone, suggesting that alcohol in the combination of glucose induces reactive hypoglycemia.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三好 秀明

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