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Hokkaido University Collection of Scholarly and Academic Papers >
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Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer |
| Authors: | Hirofumi, Morimoto Browse this author | | Yasuhiro, Hida Browse this author →KAKEN DB | | Nako, Maishi Browse this author →KAKEN DB | | Nishihara, Hiroshi Browse this author →KAKEN DB | | Hatanaka, Yutaka Browse this author →KAKEN DB | | Li, Cong Browse this author | | Matsuno, Yoshihiro Browse this author →KAKEN DB | | Nakamura, Toru Browse this author →KAKEN DB | | Hirano, Satoshi Browse this author →KAKEN DB | | Hida, Kyoko Browse this author →KAKEN DB |
| Keywords: | angiogenesis | | biglycan | | endothelial cell | | lung cancer | | tumor progression |
| Issue Date: | 11-Mar-2021 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Thoracic Cancer |
| Volume: | 12 |
| Issue: | 9 |
| Start Page: | 1347 |
| End Page: | 1357 |
| Publisher DOI: | 10.1111/1759-7714.13907 |
| PMID: | 33709550 |
| Abstract: | Objectives In lung cancer, surgery remains the most curative treatment and limited resection is beneficial for patients with low cardiopulmonary function and low malignancy tumors. However, there are no biomarkers of low malignancy to select candidates for limited resection without compromising the outcome of treatments. Recently we identified biglycan (BGN) as a tumor endothelial cell (TEC) marker that is associated with tumor progression in various cancers. In this study, we analyzed the association between BGN expression in TECs in lung cancer and cancer progression in patients. Materials and Methods First, we performed immunohistochemistry of BGN with resected lung tumor tissues of 155 patients who had undergone thoracic surgery and analyzed the correlation between BGN-positive vessel density in primary lung tumors and clinicopathological factors. Second, we measured the BGN levels in preoperative serum of other 46 patients with lung cancer by ELISA, and analyzed the correlation between BGN expression in tumor tissues and blood BGN levels. Results High BGN expression in the TECs was significantly associated with T factor, and was a significant negative predictor. BGN levels in preoperative serum of 46 patients with lung cancer was significantly correlated with BGN expression in the TECs. Preoperative serum BGN level was significantly lower in healthy volunteers and less invasive adenocarcinoma than in invasive adenocarcinoma and other lung carcinomas. These results suggest that low BGN level in preoperative serum in patients with lung cancer might indicate low malignancy. Conclusions BGN can be a potential biomarker for lung cancer. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81151 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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