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Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study

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Title: Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study
Authors: Hata, Hironobu Browse this author →KAKEN DB
Takada, Shinya Browse this author
Sato, Jun Browse this author →KAKEN DB
Yoshikawa, Kazuhito Browse this author →KAKEN DB
Imamachi, Kenji Browse this author →KAKEN DB
Edo, Minako Browse this author
Sagawa, Tamotsu Browse this author
Fujikawa, Koshi Browse this author
Ueda, Michihiro Browse this author
Matsuzaka, Masashi Browse this author →KAKEN DB
Kitagawa, Yoshimasa Browse this author →KAKEN DB
Keywords: analgesic effect
cancer therapy
indomethacin spray
oral mucositis pain
quality of life
Issue Date: 18-Mar-2021
Publisher: John Wiley & Sons
Journal Title: Special care in dentistry
Publisher DOI: 10.1111/scd.12587
PMID: 33735535
Abstract: Aims: Symptomatic treatment is insufficient for chemotherapy- or targeted therapy-induced oral mucositis (OM) pain, and benzydamine mouthwash is not commercially available in Japan. We evaluated the analgesic effects of an in-hospital preparation of 0.25% indomethacin spray (IMS) on anticancer drug-induced OM pain. Methods: This single-arm prospective trial enrolled 20 patients (median age 62.0 years) with OM and numerical rating scale scores of >= 5 who were undergoing chemotherapy or targeted therapy in our hospital. Pain scores were recorded using a visual analog scale (VAS) before and 30 min after IMS administration. Pain relief (PR) scores were recorded at 15, 30, and 60 min after IMS administration; total PR after 60 min (TOTPAR(60)) was calculated, and the mean PR score after 3 days (PR3days) was determined. Results: The median (interquartile range) OM grade of the participants was 2.0 (2.0-2.3). The VAS score decreased significantly at 30 min after IMS administration (p = .001). The median (interquartile range) TOTPAR(60) and PR3days were 6.0 (3.8-7.3) and 2.0 (2.0-3.0), respectively. Conclusions: IMS helped improve patients' quality of life. The risk of systemic adverse effects was low because of the low dose administered. IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/81152
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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