HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
International Institute for Zoonosis Control >
Peer-reviewed Journal Articles, etc >

An African tick flavivirus forming an independent clade exhibits unique exoribonuclease-resistant RNA structures in the genomic 3 '-untranslated region

This item is licensed under: Creative Commons Attribution 4.0 International

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: An African tick flavivirus forming an independent clade exhibits unique exoribonuclease-resistant RNA structures in the genomic 3 '-untranslated region
Authors: Harima, Hayato Browse this author →KAKEN DB
Orba, Yasuko Browse this author →KAKEN DB
Torii, Shiho Browse this author →KAKEN DB
Qiu, Yongjin Browse this author →KAKEN DB
Kajihara, Masahiro Browse this author →KAKEN DB
Eto, Yoshiki Browse this author
Matsuta, Naoya Browse this author
Hang'ombe, Bernard M. Browse this author
Eshita, Yuki Browse this author →KAKEN DB
Uemura, Kentaro Browse this author
Matsuno, Keita Browse this author →KAKEN DB
Sasaki, Michihito Browse this author →KAKEN DB
Yoshii, Kentaro Browse this author →KAKEN DB
Nakao, Ryo Browse this author →KAKEN DB
Hall, William W. Browse this author
Takada, Ayato Browse this author →KAKEN DB
Abe, Takashi Browse this author →KAKEN DB
Wolfinger, Michael T. Browse this author
Simuunza, Martin Browse this author
Sawa, Hirofumi Browse this author →KAKEN DB
Issue Date: 1-Mar-2021
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 11
Issue: 1
Start Page: 4883
Publisher DOI: 10.1038/s41598-021-84365-9
Abstract: Tick-borne flaviviruses (TBFVs) infect mammalian hosts through tick bites and can cause various serious illnesses, such as encephalitis and hemorrhagic fevers, both in humans and animals. Despite their importance to public health, there is limited epidemiological information on TBFV infection in Africa. Herein, we report that a novel flavivirus, Mpulungu flavivirus (MPFV), was discovered in a Rhipicephalus muhsamae tick in Zambia. MPFV was found to be genetically related to Ngoye virus detected in ticks in Senegal, and these viruses formed a unique lineage in the genus Flavivirus. Analyses of dinucleotide contents of flaviviruses indicated that MPFV was similar to those of other TBFVs with a typical vertebrate genome signature, suggesting that MPFV may infect vertebrate hosts. Bioinformatic analyses of the secondary structures in the 3 ' -untranslated regions (UTRs) revealed that MPFV exhibited unique exoribonuclease-resistant RNA (xrRNA) structures. Utilizing biochemical approaches, we clarified that two xrRNA structures of MPFV in the 3 ' -UTR could prevent exoribonuclease activity. In summary, our findings provide new information regarding the geographical distribution of TBFV and xrRNA structures in the 3 ' -UTR of flaviviruses.
Type: article
Appears in Collections:人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University