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Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study

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Title: Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study
Authors: Yamada, Hiroya Browse this author
Suzuki, Koji Browse this author
Fujii, Ryosuke Browse this author
Kawado, Miyuki Browse this author
Hashimoto, Shuji Browse this author
Watanabe, Yoshiyuki Browse this author
Iso, Hiroyasu Browse this author
Fujino, Yoshihisa Browse this author
Wakai, Kenji Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Issue Date: 5-Mar-2021
Publisher: Nature Research
Journal Title: Scientific reports
Volume: 11
Start Page: 5298
Publisher DOI: 10.1038/s41598-021-84707-7
Abstract: Primary prevention of premature death is a public health concern worldwide. Circulating microRNAs (miRNAs) have been described as potential diagnostic biomarkers for diseases as cancer and cardiovascular disease (CVD). This case-cohort study aimed to investigate the potential relationship between circulating miRNAs and the risk of premature death. A total of 39,242 subjects provided baseline serum samples in 1988-1990. Of these, 345 subjects who died of intrinsic disease (<65 years old) and for which measurable samples were available were included in this study. We randomly selected a sub-cohort of 879 subjects. Circulatring miR-21, miR-29a, and miR-126 were determined using qRT-PCR. Conditional logistic regression models were used to analyse the data with respect to stratified miRNA levels. Multivariable logistic regression revealed that subjects with high circulating miR-21 and miR-29a individual levels had a significantly higher risk of total death, cancer death, and CVD death than those with medium miR-21 and miR-29a individual levels. Conversely, subjects with low circulating miR-126 levels had a significantly higher risk of total death than those with medium levels. This suggests that circulating miRNAs are associated with the risk of premature death from cancer and CVD, identifying them as potential biomarkers for early detection of high-risk individuals.
Rights: http://creat iveco mmons .org/licen ses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/81220
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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