HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys

This item is licensed under:Creative Commons Attribution 4.0 International

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys
Authors: Kadono, Yoshinori Browse this author
Koguchi, Keigo Browse this author
Okada, Ken-ichi Browse this author
Hosomi, Koichi Browse this author
Hiraishi, Motoki Browse this author
Ueguchi, Takashi Browse this author
Kida, Ikuhiro Browse this author
Shah, Adnan Browse this author
Liu, Guoxiang Browse this author
Saitoh, Youichi Browse this author
Issue Date: 17-Mar-2021
Publisher: Nature Research
Journal Title: Scientific reports
Volume: 11
Start Page: 6126
Publisher DOI: 10.1038/s41598-021-85409-w
Abstract: Central poststroke pain (CPSP) develops after a stroke around the somatosensory pathway. CPSP is hypothesized to be caused by maladaptive reorganization between various brain regions. The treatment for CPSP has not been established; however, repetitive transcranial magnetic stimulation (rTMS) to the primary motor cortex has a clinical effect. To verify the functional reorganization hypothesis for CPSP development and rTMS therapeutic mechanism, we longitudinally pursued the structural and functional changes of the brain by using two male CPSP model monkeys (Macaca fuscata) developed by unilateral hemorrhage in the ventral posterolateral nucleus of the thalamus. Application of rTMS to the ipsilesional primary motor cortex relieved the induced pain of the model monkeys. A tractography analysis revealed a decrease in the structural connectivity in the ipsilesional thalamocortical tract, and rTMS had no effect on the structural connectivity. A region of interest analysis using resting-state functional magnetic resonance imaging revealed inappropriately strengthened functional connectivity between the ipsilesional mediodorsal nucleus of the thalamus and the amygdala, which are regions associated with emotion and memory, suggesting that this may be the cause of CPSP development. Moreover, rTMS normalizes this strengthened connectivity, which may be a possible therapeutic mechanism of rTMS for CPSP.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University