|
Hokkaido University Collection of Scholarly and Academic Papers >
Global Institution for Collaborative Research and Education : GI-CoRE >
Peer-reviewed Journal Articles, etc >
Host-directed editing of the SARS-CoV-2 genome
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | Host-directed editing of the SARS-CoV-2 genome |
| Authors: | Mourier, Tobias Browse this author | | Sadykov, Mukhtar Browse this author | | Carr, Michael J. Browse this author →KAKEN DB | | Gonzalez, Gabriel Browse this author | | Hall, William W. Browse this author | | Pain, Arnab Browse this author |
| Keywords: | SARS-CoV-2 | | Virus evolution | | Genome editing | | ADAR | | APOBEC | | ROS |
| Issue Date: | 29-Jan-2021 |
| Publisher: | Elsevier |
| Journal Title: | Biochemical and biophysical research communications |
| Volume: | 538 |
| Start Page: | 35 |
| End Page: | 39 |
| Publisher DOI: | 10.1016/j.bbrc.2020.10.092 |
| Abstract: | The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution. (c) 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81355 |
| Appears in Collections: | 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
