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Host-directed editing of the SARS-CoV-2 genome

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Title: Host-directed editing of the SARS-CoV-2 genome
Authors: Mourier, Tobias Browse this author
Sadykov, Mukhtar Browse this author
Carr, Michael J. Browse this author →KAKEN DB
Gonzalez, Gabriel Browse this author
Hall, William W. Browse this author
Pain, Arnab Browse this author
Keywords: SARS-CoV-2
Virus evolution
Genome editing
Issue Date: 29-Jan-2021
Publisher: Elsevier
Journal Title: Biochemical and biophysical research communications
Volume: 538
Start Page: 35
End Page: 39
Publisher DOI: 10.1016/j.bbrc.2020.10.092
Abstract: The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution. (c) 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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