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Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model

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Title: Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model
Authors: Tian, Yuan Browse this author
Onodera, Tomohiro Browse this author →KAKEN DB
Terkawi, Mohamad Alaa Browse this author
Iwasaki, Koji Browse this author →KAKEN DB
Hishimura, Ryosuke Browse this author
Liang, Dawei Browse this author
Miyazaki, Takuji Browse this author
Iwasaki, Norimasa Browse this author →KAKEN DB
Keywords: osteoarthritis
nerve growth factor (NGF)
intra-articular injection
Issue Date: Mar-2021
Publisher: MDPI
Journal Title: International Journal of Molecular Sciences
Volume: 22
Issue: 5
Start Page: 2552
Publisher DOI: 10.3390/ijms22052552
Abstract: Systemic injection of a nerve growth factor (NGF) antibody has been proven to have a significant relevance in relieving osteoarthritis (OA) pain, while its adverse effects remain a safety concern for patients. A local low-dose injection is thought to minimize adverse effects. In this study, OA was induced in an 8-week-old male Sprague-Dawley (SD) rat joint by monoiodoacetate (MIA) injection for 2 weeks, and the effect of weekly injections of low-dose (1, 10, and 100 mu g) NGF antibody or saline (control) was evaluated. Behavioral tests were performed, and at the end of week 6, all rats were sacrificed and their knee joints were collected for macroscopic and histological evaluations. Results showed that 100 mu g NGF antibody injection relieved pain in OA rats, as evidenced from improved weight-bearing performance but not allodynia. In contrast, no significant differences were observed in macroscopic and histological scores between rats from different groups, demonstrating that intra-articular treatment does not worsen OA progression. These results suggest that local administration yielded a low effective NGF antibody dose that may serve as an alternative approach to systemic injection for the treatment of patients with OA.
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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