| Title: | Baseline serum angiopoietin-2 and VEGF levels predict the deterioration of the liver functional reserve during lenvatinib treatment for hepatocellular carcinoma |
| Authors: | Shigesawa, Taku Browse this author |
| Suda, Goki Browse this author →KAKEN DB |
| Kimura, Megumi Browse this author |
| Maehara, Osamu Browse this author |
| Tokuchi, Yoshimasa Browse this author |
| Kubo, Akinori Browse this author |
| Yamada, Ren Browse this author |
| Furuya, Ken Browse this author |
| Baba, Masaru Browse this author |
| Kitagataya, Takashi Browse this author |
| Suzuki, Kazuharu Browse this author |
| Ohara, Masatsugu Browse this author |
| Kawagishi, Naoki Browse this author |
| Nakai, Masato Browse this author |
| Sho, Takuya Browse this author |
| Natsuizaka, Mitsuteru Browse this author |
| Morikawa, Kenichi Browse this author |
| Ogawa, Koji Browse this author |
| Sakamoto, Naoya Browse this author |
| Issue Date: | 1-Mar-2021 |
| Publisher: | PLOS |
| Journal Title: | PLoS ONE |
| Volume: | 16 |
| Issue: | 3 |
| Start Page: | e0247728 |
| Publisher DOI: | 10.1371/journal.pone.0247728 |
| Abstract: | A deteriorated liver functional reserve during systemic therapy for unresectable hepatocellular carcinoma (HCC) causes poor patient outcomes. We aimed to identify predictive factors associated with the deterioration of Child-Pugh score at 8 weeks after lenvatinib initiation. Patients with adequate clinical data and baseline preserved serum samples available were included. Baseline fibroblast growth factor (FGF)19 and 21, angiopoietin (ANG)2, and vascular endothelial growth factor (VEGF) levels were evaluated. Thirty-seven patients were included, and 6, 15, 14, and 2 experienced complete response, partial response, stable disease, and progressive disease, respectively. Twenty-four (65%) and 13 (35%) patients showed a maintained/improved and deteriorated Child-Pugh-score, respectively. While baseline clinical data, treatment response, and laboratory data were similar between these two patient groups, baseline ANG2 and VEGF levels were significantly higher (P = 0.0017) and lower (P = 0.0231), respectively, in patients with deteriorated Child-Pugh score than in those without. Based on receiver operating characteristic curve analysis, cut-off values for ANG2 and VEGF were found to be 3,108 pg/mL and 514.9 pg/mL, respectively. Among patients with low VEGF and high ANG2, 89% (8/9) exhibited a deteriorated Child-Pugh score, whereas none of the patients (0/9) with high VEGF and low ANG2 did. The deterioration of the Child-Pugh score in patients with unresectable HCC who are treated with lenvatinib may be predictable based on combined baseline serum ANG2 and VEGF levels. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81363 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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