HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >

Short communication : Menaquinone-4 (vitamin K-2) induces proliferation responses in bovine peripheral blood mononuclear cells

This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Files in This Item:
J. Dairy Sci.103-8_7531-7534.pdf436.01 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Short communication : Menaquinone-4 (vitamin K-2) induces proliferation responses in bovine peripheral blood mononuclear cells
Authors: Bai, H. Browse this author →KAKEN DB
Hiura, H. Browse this author
Obara, Y. Browse this author
Kawahara, M. Browse this author →KAKEN DB
Takahashi, M. Browse this author
Keywords: cow
peripheral blood mononuclear cells
Issue Date: Aug-2020
Publisher: Elsevier
Journal Title: Journal of dairy science
Volume: 103
Issue: 8
Start Page: 7531
End Page: 7534
Publisher DOI: 10.3168/jds.2019-17987
Abstract: The effects of vitamin K (VK) on immune cells in ruminants are yet to be fully investigated. The objective of this study was to examine the effects of VK on peripheral blood mononuclear cells (PBMC) in Holstein dairy cows. A cell proliferation assay was performed to evaluate the effect of menaquinone-4 (MK-4, the biologically active form of VK) on immune response of PBMC. The proliferation of PBMC stimulated by MK-4 was significantly higher than that of nonstimulated controls. The expression of T cell-related genes in PBMC, stimulated with MK-4, was assessed by quantitative PCR. No significant changes were observed in the mRNA expression levels of both CD4 and CD8 as helper T cell and cytotoxic T cell markers, respectively. The present study demonstrated that MK-4 positively influenced cow PBMC proliferation and suggested the possibility of bovine-specific immune cell activation. The present study lays a foundation for understanding the physiological role of VK in cattle.
Rights: ©2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 唄 花子

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University