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Severe infection including disseminated herpes zoster triggered by subclinical Cushing's disease: a case report
| Title: | Severe infection including disseminated herpes zoster triggered by subclinical Cushing's disease: a case report |
| Authors: | Yamauchi, Yuki Browse this author | | Kameda, Hiraku Browse this author →KAKEN DB | | Omori, Kazuno Browse this author | | Tani, Michio Browse this author | | Cho, Kyu Yong Browse this author | | Nakamura, Akinobu Browse this author | | Miyoshi, Hideaki Browse this author | | Tanaka, Shinya Browse this author | | Atsumi, Tatsuya Browse this author |
| Keywords: | Subclinical Cushing’s disease | | Disseminated herpes zoster | | Infection |
| Issue Date: | 27-Apr-2021 |
| Publisher: | BioMed Central |
| Journal Title: | BMC Endocrine Disorders |
| Volume: | 21 |
| Issue: | 1 |
| Start Page: | 84 |
| Publisher DOI: | 10.1186/s12902-021-00757-y |
| Abstract: | Background Subclinical Cushing's disease (SCD) is defined by corticotroph adenoma-induced mild hypercortisolism without typical physical features of Cushing's disease. Infection is an important complication associated with mortality in Cushing's disease, while no reports on infection in SCD are available. To make clinicians aware of the risk of infection in SCD, we report a case of SCD with disseminated herpes zoster (DHZ) with the mortal outcome. Case presentation An 83-year-old Japanese woman was diagnosed with SCD, treated with cabergoline in the outpatient. She was hospitalized for acute pyelonephritis, and her fever gradually resolved with antibiotics. However, herpes zoster appeared on her chest, and the eruptions rapidly spread over the body. She suddenly went into cardiopulmonary arrest and died. Autopsy demonstrated adrenocorticotropic hormone-positive pituitary adenoma, renal abscess, and DHZ. Conclusions As immunosuppression caused by SCD may be one of the triggers of severe infection, the patients with SCD should be assessed not only for the metabolic but also for the immunodeficient status. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81600 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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