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Host serine proteases TMPRSS2 and TMPRSS11D mediate proteolytic activation and trypsin-independent infection in group A rotaviruses

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Title: Host serine proteases TMPRSS2 and TMPRSS11D mediate proteolytic activation and trypsin-independent infection in group A rotaviruses
Authors: Sasaki, Michihito Browse this author →KAKEN DB
Itakura, Yukari Browse this author
Kishimoto, Mai Browse this author
Tabata, Koshiro Browse this author
Uemura, Kentaro Browse this author
Ito, Naoto Browse this author →KAKEN DB
Sugiyama, Makoto Browse this author →KAKEN DB
Wastika, Christida E Browse this author
Orba, Yasuko Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Keywords: group A rotavirus
proteolytic activation
type II transmembrane serine proteases
VP4
viral entry
Issue Date: Jun-2021
Publisher: American Society for Microbiology
Journal Title: Journal of virology
Volume: 95
Issue: 11
Start Page: e00398-21
Publisher DOI: 10.1128/JVI.00398-21
PMID: 33762412
Abstract: Group A rotaviruses (RVAs) are representative enteric virus species and major causes of diarrhea in humans and animals. The RVA virion is a triple-layered particle, and the outermost layer consists of the glycoprotein VP7 and spike protein VP4. To increase the infectivity of RVA, VP4 is proteolytically cleaved into VP5* and VP8* subunits by trypsin; and these subunits form a rigid spike structure on the virion surface. In this study, we investigated the growth of RVAs in cells transduced with type II transmembrane serine proteases (TTSPs), which cleave fusion proteins and promote infection by respiratory viruses, such as influenza viruses, paramyxoviruses, and coronaviruses. We identified TMPRSS2 and TMPRSS11D as host TTSPs that mediate trypsin-independent and multi-cycle infection by human and animal RVA strains.
Type: article
URI: http://hdl.handle.net/2115/81748
Appears in Collections:人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐々木 道仁

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