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Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation

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Title: Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation
Authors: Hagio, Masahito Browse this author
Shimizu, Hidehisa Browse this author
Joe, Ga-Hyun Browse this author
Takatsuki, Manami Browse this author
Shiwaku, Maiko Browse this author
Xu, Hong Browse this author
Lee, Ja-Young Browse this author
Fujii, Nobuyuki Browse this author
Fukiya, Satoru Browse this author →KAKEN DB
Hara, Hiroshi Browse this author →KAKEN DB
Yokota, Atsushi Browse this author →KAKEN DB
Ishizuka, Satoshi Browse this author →KAKEN DB
Keywords: Bile acid
Intestinal epithelial kinetics
Ultra performance liquid chromatography-electrospray ionization mass spectrometry
Cecal contents
IEC-6 cells
Issue Date: Jan-2015
Publisher: Elsevier
Journal Title: Toxicology Letters
Volume: 232
Issue: 1
Start Page: 246
End Page: 252
Publisher DOI: 10.1016/j.toxlet.2014.10.011
Abstract: Consumption of a high-fat diet increases some secondary bile acids (BAs) such as deoxycholic acid (DCA) in feces. DCA is derived from cholic acid (CA), a primary BA. We evaluated intestinal epithelial proliferation and BA metabolism in response to oral administration of cholic acid (CA) in rats to determine the influence of a CA diet on the responses of gut epithelia to γ-rays. WKAH/HkmSlc rats were divided into two dietary groups: control diet or CA-supplemented (2 g/kg diet) diet. Some of the rats from each group were irradiated with γ-rays, and epithelial cell proliferation in the colon was analyzed histochemically. Unirradiated CA-fed rats had high levels of DCA and CA in the sera, as well as the presence of taurocholic acid in their feces. Significant increases were observed in both epithelial proliferation and the number of epithelial cells in the colon of the CA-fed rats, and this effect was observed at 8 weeks after γ-ray exposure. Furthermore, extracts from both cecal contents and sera of the unirradiated CA-fed rats promoted proliferation of IEC-6 cells. These results indicate that BAs in enterohepatic circulation promote proliferation and survival of the intestinal epithelium after receiving DNA damage.
Rights: © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 敏

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