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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Marginal iron deficiency enhances liver triglyceride accumulation in rats fed a high-sucrose diet
| Title: | Marginal iron deficiency enhances liver triglyceride accumulation in rats fed a high-sucrose diet |
| Authors: | Hori, Shota Browse this author | | Hara, Hiroshi Browse this author →KAKEN DB | | Ishizuka, Satoshi Browse this author →KAKEN DB |
| Keywords: | Marginal iron deficiency | | liver lipid accumulation | | fatty acid synthase |
| Issue Date: | Dec-2018 |
| Journal Title: | Bioscience, Biotechnology, and Biochemistry |
| Volume: | 82 |
| Issue: | 12 |
| Start Page: | 2140 |
| End Page: | 2148 |
| Publisher DOI: | 10.1080/09168451.2018.1515616 |
| Abstract: | We investigated whether marginal iron-deficiency (MID) without anemia influences liver lipid accumulation in rats. Ingestion of a MID diet in which the iron concentration was half of AIN-93 formulation (iron-adequate, IA) for 3 weeks decreased liver iron concentration without anemia. We then evaluated the influence of the MID diet on liver lipid accumulation in combination with a high-sucrose (HS) diet and confirmed that the HS-MID diet successfully decreased liver iron concentration without anemia. Additionally, a significant increase in liver triglyceride concentration was found, accompanied by upregulation of hepatic fatty acid synthase expression in the rats fed the HS-MID diet compared to those in the rats fed an HS-IA diet, although no difference was observed in plasma transaminase activity and hepatic interleukin-1β expression. These results suggest that MID enhances de novo lipid synthesis via upregulation of lipogenic gene expression in combination with sucrose in the diet. |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience biotechnology and biochemistry following peer review. The version of record Shota Hori, Hiroshi Hara, Satoshi Ishizuka, Marginal iron deficiency enhances liver triglyceride accumulation in rats fed a high-sucrose diet, Bioscience, Biotechnology, and Biochemistry, Volume 82, Issue 12, 2 December 2018, Pages 2140-2148, is available online at: https://doi.org/10.1080/09168451.2018.1515616 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/81758 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石塚 敏
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