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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet
| Title: | Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet |
| Authors: | Lee, Dong Geun Browse this author | | Hori, Shota Browse this author | | Kohmoto, Ohji Browse this author | | Kitta, Shinri Browse this author | | Yoshida, Ryo Browse this author | | Tanaka, Yasutake Browse this author | | Shimizu, Hidehisa Browse this author | | Takahashi, Keisuke Browse this author | | Nagura, Taizo Browse this author | | Uchino, Hirokatsu Browse this author | | Fukiya, Satoru Browse this author →KAKEN DB | | Yokota, Atsushi Browse this author →KAKEN DB | | Ishizuka, Satoshi Browse this author →KAKEN DB |
| Keywords: | Difructose anhydride III | | bile acid | | deconjugation | | 7α-dehydroxylation |
| Issue Date: | Jul-2019 |
| Journal Title: | Bioscience, Biotechnology, and Biochemistry |
| Volume: | 83 |
| Issue: | 7 |
| Start Page: | 1329 |
| End Page: | 1335 |
| Publisher DOI: | 10.1080/09168451.2019.1597617 |
| Abstract: | Difructose anhydride III (DFAIII) is a prebiotic involved in the reduction of secondary bile acids (BAs). We investigated whether DFAIII modulates BA metabolism, including enterohepatic circulation, in the rats fed with a diet supplemented with cholic acid (CA), one of the 12αhydroxylated BAs. After acclimation, the rats were fed with a control diet or a diet supplemented with DFAIII. After 2 weeks, each group was further divided into two groups and was fed diet with or without CA supplementation at 0.5 g/kg diet. BA levels were analyzed in aortic and portal plasma, liver, intestinal content, and feces. As a result, DFAIII ingestion reduced the fecal deoxycholic acid level via the partial suppression of deconjugation and 7αdehydroxylation of BAs following CA supplementation. These results suggest that DFAIII suppresses production of deoxycholic acid in conditions of high concentrations of 12αhydroxylated BAs in enterohepatic circulation, such as obesity or excess energy intake. |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience biotechnology and biochemistry following peer review. The version of record Dong Geun Lee, Shota Hori, Ohji Kohmoto, Shinri Kitta, Ryo Yoshida, Yasutake Tanaka, Hidehisa Shimizu, Keisuke Takahashi, Taizo Nagura, Hirokatsu Uchino, Satoru Fukiya, Atsushi Yokota, Satoshi Ishizuka, Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet, Bioscience, Biotechnology, and Biochemistry, Volume 83, Issue 7, 3 July 2019, Pages 1329-1335, is available online at: https://doi.org/10.1080/09168451.2019.1597617. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/81807 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石塚 敏
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