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Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin
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| Title: | Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin |
| Authors: | Miyashita, Kazuo Browse this author →KAKEN DB | | Beppu, Fumiaki Browse this author →KAKEN DB | | Hosokawa, Masashi Browse this author →KAKEN DB | | Liu, Xiaoyong Browse this author | | Wang, Shuzhou Browse this author |
| Keywords: | Brown seaweeds | | Fucoxanthin | | Anti-obesity | | Anti-diabetes | | Anti-cancer |
| Issue Date: | 15-Jun-2020 |
| Publisher: | Elsevier |
| Journal Title: | Archives of biochemistry and biophysics |
| Volume: | 686 |
| Start Page: | 108364 |
| Publisher DOI: | 10.1016/j.abb.2020.108364 |
| Abstract: | Fucoxanthin (Fx), a major carotenoid found in brown seaweed, is known to show a unique and wide variety of biological activities. Upon absorption, Fx is metabolized to fucoxanthinol and amarouciaxanthin, and these metabolites mainly accumulate in visceral white adipose tissue (WAT). As seen in other carotenoids, Fx can quench singlet oxygen and scavenge a wide range of free radicals. The antioxidant activity is related to the neuroprotective, photoprotective, and hepatoprotective effects of Fx. Fx is also reported to show anti-cancer activity through the regulation of several biomolecules and signaling pathways that are involved in either cell cycle arrest, apoptosis, or metastasis suppression. Among the biological activities of Fx, anti-obesity is the most well-studied and most promising effect. This effect is primarily based on the upregulation of thermogenesis by uncoupling protein 1 expression and the increase in the metabolic rate induced by mitochondrial activation. In addition, Fx shows anti-diabetic effects by improving insulin resistance and promoting glucose utilization in skeletal muscle. |
| Rights: | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/81864 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮下 和夫
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