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Evaluation of antibacterial and cytocompatible properties of multiple-ion releasing zinc-fluoride glass nanoparticles

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Title: Evaluation of antibacterial and cytocompatible properties of multiple-ion releasing zinc-fluoride glass nanoparticles
Authors: Nishida, Erika Browse this author →KAKEN DB
Miyaji, Hirofumi Browse this author →KAKEN DB
Shitomi, Kanako Browse this author →KAKEN DB
Sugaya, Tsutomu Browse this author →KAKEN DB
Akasaka, Tsukasa Browse this author →KAKEN DB
Keywords: Actinomyces naeslundii
Biocompatibility
Dentin
Streptococcus mutans
Zinc-fluoride glass nanoparticles
Issue Date: Feb-2021
Publisher: 日本歯科理工学会(The Japanese Society for Dental Materials and Devices)
Journal Title: Dental materials journal
Volume: 40
Issue: 1
Start Page: 157
End Page: 164
Publisher DOI: 10.4012/dmj.2019-176
PMID: 32999216
Abstract: Zinc-fluoride glass nanoparticles (Zinc-F) release several ions, such as fluoride, zinc and calcium ions, through acid-base reactions. The aim of this study was to evaluate the antibacterial and cytotoxic properties of Zinc-F. Antibacterial tests showed that a Zinc-F eluting solution significantly reduced the turbidity and colony-forming units of Streptococcus mutans and Actinomyces naeslundii, compared to that of calcium-fluoroaluminosilicate glass nanoparticles without zinc ions. In live/dead staining, Zinc-F eluate significantly decreased green-stained bacterial cells, indicating live cells, compared with the control (no application). Human dentin coated with Zinc-F showed suppressed S. mutans and A. naeslundii biofilm formation. Additionally, Zinc-F eluate showed low cytotoxic effects in osteoblastic and fibroblastic cells. Therefore, our findings suggested that Zinc-F exhibits antibacterial and biocompatible properties through multiple-ion release.
Type: article
URI: http://hdl.handle.net/2115/81903
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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