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Antibacterial Effect of Amino Acid-Silver Complex Loaded Montmorillonite Incorporated in Dental Acrylic Resin

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Title: Antibacterial Effect of Amino Acid-Silver Complex Loaded Montmorillonite Incorporated in Dental Acrylic Resin
Authors: Yoshihara, Kumiko Browse this author →KAKEN DB
Nagaoka, Noriyuki Browse this author →KAKEN DB
Umeno, Aya Browse this author
Sonoda, Akinari Browse this author →KAKEN DB
Obika, Hideki Browse this author →KAKEN DB
Yoshida, Yasuhiro Browse this author →KAKEN DB
Van Meerbeek, Bart Browse this author
Makita, Yoji Browse this author →KAKEN DB
Keywords: montmorillonite
amino acid
Streptococcus mutans
nuclear magnetic resonance
X-ray diffraction
Issue Date: Mar-2021
Publisher: MDPI
Journal Title: Materials
Volume: 14
Issue: 6
Start Page: 1442
Publisher DOI: 10.3390/ma14061442
PMID: 33809621
Abstract: Several dental materials contain silver for antibacterial effect, however the effect is relatively low. The reason for the lower antibacterial efficacy of silver is considered to be the fact that silver ions bind to chloride ions in saliva. To develop new effective silver antibacterial agents that can be useful in the mouth, we synthesized two novel amino acid (methionine or histidine)-silver complexes (Met or His-Ag) loaded with montmorillonite (Mont) and analyzed their antibacterial efficacy. At first the complexes were characterized using nuclear magnetic resonance (NMR), and amino acid-Ag complex-loaded Mont (amino acid-Ag-Mont) were characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The antibacterial efficacy of these materials in dental acrylic resin was then investigated by bacterial growth measurement using a spectrophotometer. As controls, commercially available silver-loaded zeolite and silver-zirconium phosphate were also tested. Dental acrylic resin incorporating His-Ag-Mont strongly inhibited Streptococcus mutans growth. This was explained by the fact that His-Ag complex revealed the highest amounts of silver ions in the presence of chloride. The structure of the amino acid-Ag complexes affected the silver ion presence in chloride and the antibacterial efficacy. His-Ag-Mont might be used as antibacterial agents for dental materials.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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