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Hokkaido University Collection of Scholarly and Academic Papers >
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Long-term prognostic factors of patients with hepatocellular carcinoma who survive over 10 years after hepatectomy
| Title: | Long-term prognostic factors of patients with hepatocellular carcinoma who survive over 10 years after hepatectomy |
| Authors: | Shimada, Shingo Browse this author →KAKEN DB | | Kamiyama, Toshiya Browse this author →KAKEN DB | | Orimo, Tatsuya Browse this author | | Nagatsu, Akihisa Browse this author | | Asahi, Yoh Browse this author | | Sakamoto, Yuzuru Browse this author | | Kamachi, Hirofumi Browse this author →KAKEN DB | | Taketomi, Akinobu Browse this author →KAKEN DB |
| Keywords: | hepatectomy | | hepatocellular carcinoma | | long-term prognoses | | nonviral hepatitis | | solitary intrahepatic recurrence |
| Issue Date: | 15-Jun-2020 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 121 |
| Issue: | 8 |
| Start Page: | 1209 |
| End Page: | 1217 |
| Publisher DOI: | 10.1002/jso.25910 |
| Abstract: | Background and Objectives The aim was to evaluate long-term prognostic factors in hepatocellular carcinoma (HCC) patients who survived over 10 years after hepatectomy and compare prognostic factors between patients with recurrence who died and survived 10 years after initial hepatectomy. Methods We analyzed the HCC patients without recurrence over 10 years after hepatectomy (n = 35), those with recurrence who survived over 10 years (n = 48), and those who died within 10 years (n = 132). Results The rate of recurrence was 16.3%, 10-year overall survival rate was 38.6%, and the 10-year recurrence-free survival (RFS) rate was 16.7%. Nonviral, solitary tumor, well differentiation, and without severe fibrosis were independent favorable factors for long-term RFS. High cholinesterase levels, small tumors and without portal vein invasion were independent favorable factors for long-term survival among patients with recurrence. Long-term survivors with recurrence showed significantly low early recurrence, extrahepatic recurrence, multiple intrahepatic recurrences. Conclusion Important factors for long-term prognoses in HCC patients were a solitary tumor, small tumors, and no advanced fibrosis. A treatment for nonviral hepatitis is needed to achieve long-term RFS. Even patients who relapse might survive long term if they have a late or solitary intrahepatic recurrence, nonsevere cirrhosis, and curative treatment at recurrence. |
| Rights: | This is the peer reviewed version of the following article: Shimada, S, Kamiyama, T, Orimo, T, et al. Long‐term prognostic factors of patients with hepatocellular carcinoma who survive over 10 years after hepatectomy. J Surg Oncol. 2020; 121: 1209-1217, which has been published in final form at https://doi.org/10.1002/jso.25910. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/81916 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 島田 慎吾
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