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Primary pulmonary lymphoepithelioma-like carcinoma with positive expression of Epstein-Barr virus and PD-L1: A case report
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| Title: | Primary pulmonary lymphoepithelioma-like carcinoma with positive expression of Epstein-Barr virus and PD-L1: A case report |
| Authors: | Sasaki, Akihiro Browse this author | | Kato, Tatsuya Browse this author | | Ujiie, Hideki Browse this author | | Cho, Yasushi Browse this author | | Sato, Masaaki Browse this author | | Kaji, Mitsuhito Browse this author |
| Keywords: | Lymphoepithelioma-like carcinoma (LELC) | | Epstein-Barr virus (EBV) | | EBV encoded small RNA (EBER) | | In situ hybridization (ISH) | | Programmed death-ligand 1 (PD-L1) | | Case report |
| Issue Date: | Feb-2021 |
| Publisher: | Elsevier |
| Journal Title: | International journal of surgery case reports |
| Volume: | 79 |
| Start Page: | 431 |
| End Page: | 435 |
| Publisher DOI: | 10.1016/j.ijscr.2021.01.066 |
| Abstract: | INTRODUCTION AND IMPORTANCE: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer (NSCLC) that is classified as a subtype of unclassified carcinoma by the WHO. LELC is usually associated with Epstein-Barr virus (EBV) infection. LELC has often been observed in Southeast Asia; however, it is extremely rare in Japan. CASE PRESENTATION: A 60-year-old Japanese woman presented with an abnormal shadow in the left lung on chest radiography. Chest computed tomography showed a nodule located between the lingular and basal anteromedial segments. A blood test suggested an existing EBV infection, and LELC was suspected preoperatively in the transbronchial lung biopsy. She underwent a lingular and basal bi-segmentectomy. The EBV-encoded small ribonucleic acid in-situ hybridization (EBER-ISH) was positive, and she was diagnosed with LELC. Moreover, programmed death-ligand 1 (PD-L1) expression was moderately positive. No recurrence was observed for 30 months. CLINICAL DISCUSSION: Although LELC has been reported as a low-grade malignancy with a good prognosis, the frequency of PD-Ll expression in LELC seems to be higher than that in other NSCLCs. Moreover, it has been reported that LELC patients with high PD-Ll expression are likely to have early recurrence/metastasis and poor prognosis. CONCLUSION: An investigation of PD-Ll expression for LELC would be useful considering the benefit of PD-1/PD-L1 blockade in patients with pulmonary LELC with high PD-Ll expression. The present case is the first report of LELC with positive expression of EBER-ISH and PD-Ll in Japan. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81921 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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