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Hokkaido University Collection of Scholarly and Academic Papers >
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Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
| Title: | Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism |
| Authors: | Lee, Ming-Liang Browse this author | | Matsunaga, Hirokazu Browse this author | | Sugiura, Yuki Browse this author →KAKEN DB | | Hayasaka, Takahiro Browse this author →KAKEN DB | | Yamamoto, Izumi Browse this author | | Ishimoto, Taiga Browse this author | | Imoto, Daigo Browse this author | | Suematsu, Makoto Browse this author →KAKEN DB | | Iijima, Norifumi Browse this author →KAKEN DB | | Kimura, Kazuhiro Browse this author →KAKEN DB | | Diano, Sabrina Browse this author | | Toda, Chitoku Browse this author →KAKEN DB |
| Issue Date: | 20-Apr-2021 |
| Publisher: | Nature Research |
| Journal Title: | Nature communications |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 2330 |
| Publisher DOI: | 10.1038/s41467-021-22431-6 |
| Abstract: | The hypothalamus plays a central role in monitoring and regulating systemic glucose metabolism. The brain is enriched with phospholipids containing poly-unsaturated fatty acids, which are biologically active in physiological regulation. Here, we show that intraperitoneal glucose injection induces changes in hypothalamic distribution and amounts of phospholipids, especially arachidonic-acid-containing phospholipids, that are then metabolized to produce prostaglandins. Knockdown of cytosolic phospholipase A2 (cPLA2), a key enzyme for generating arachidonic acid from phospholipids, in the hypothalamic ventromedial nucleus (VMH), lowers insulin sensitivity in muscles during regular chow diet (RCD) feeding. Conversely, the down-regulation of glucose metabolism by high fat diet (HFD) feeding is improved by knockdown of cPLA2 in the VMH through changing hepatic insulin sensitivity and hypothalamic inflammation. Our data suggest that cPLA2-mediated hypothalamic phospholipid metabolism is critical for controlling systemic glucose metabolism during RCD, while continuous activation of the same pathway to produce prostaglandins during HFD deteriorates glucose metabolism. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/81956 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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