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Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism

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Title: Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
Authors: Lee, Ming-Liang Browse this author
Matsunaga, Hirokazu Browse this author
Sugiura, Yuki Browse this author →KAKEN DB
Hayasaka, Takahiro Browse this author →KAKEN DB
Yamamoto, Izumi Browse this author
Ishimoto, Taiga Browse this author
Imoto, Daigo Browse this author
Suematsu, Makoto Browse this author →KAKEN DB
Iijima, Norifumi Browse this author →KAKEN DB
Kimura, Kazuhiro Browse this author →KAKEN DB
Diano, Sabrina Browse this author
Toda, Chitoku Browse this author →KAKEN DB
Issue Date: 20-Apr-2021
Publisher: Nature Research
Journal Title: Nature communications
Volume: 12
Issue: 1
Start Page: 2330
Publisher DOI: 10.1038/s41467-021-22431-6
Abstract: The hypothalamus plays a central role in monitoring and regulating systemic glucose metabolism. The brain is enriched with phospholipids containing poly-unsaturated fatty acids, which are biologically active in physiological regulation. Here, we show that intraperitoneal glucose injection induces changes in hypothalamic distribution and amounts of phospholipids, especially arachidonic-acid-containing phospholipids, that are then metabolized to produce prostaglandins. Knockdown of cytosolic phospholipase A2 (cPLA2), a key enzyme for generating arachidonic acid from phospholipids, in the hypothalamic ventromedial nucleus (VMH), lowers insulin sensitivity in muscles during regular chow diet (RCD) feeding. Conversely, the down-regulation of glucose metabolism by high fat diet (HFD) feeding is improved by knockdown of cPLA2 in the VMH through changing hepatic insulin sensitivity and hypothalamic inflammation. Our data suggest that cPLA2-mediated hypothalamic phospholipid metabolism is critical for controlling systemic glucose metabolism during RCD, while continuous activation of the same pathway to produce prostaglandins during HFD deteriorates glucose metabolism.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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