| Title: | Determination of the cutoff values of Th2 markers for the prediction of future exacerbation in severe asthma: An analysis from the Hokkaido Severe Asthma Cohort Study |
| Authors: | Kimura, Hirokazu Browse this author |
| Makita, Hironi Browse this author |
| Taniguchi, Natsuko Browse this author |
| Takei, Nozomu Browse this author |
| Matsumoto, Munehiro Browse this author |
| Kimura, Hiroki Browse this author |
| Goudarzi, Houman Browse this author |
| Shimizu, Kaoruko Browse this author |
| Suzuki, Masaru Browse this author |
| Nishimura, Masaharu Browse this author |
| Konno, Satoshi Browse this author →KAKEN DB |
| Keywords: | Asthma |
| Biomarkers |
| Cutoff value |
| Exacerbation |
| Th2 features |
| Issue Date: | Jan-2021 |
| Publisher: | Japanese Society of Allergology |
| Journal Title: | Allergology international |
| Volume: | 70 |
| Issue: | 1 |
| Start Page: | 68 |
| End Page: | 73 |
| Publisher DOI: | 10.1016/j.alit.2020.09.001 |
| Abstract: | Background: We recently reported that severe asthma patients with frequent exacerbations showed high blood eosinophil counts (Eo) and fractions of exhaled nitric oxide (FeNO) compared with non-exacerbators. However, we did not determine exact cutoff values related to exacerbation. The aim of this study was to determine the cutoff values of Eo and FeNO that could be related to the exacerbation of severe asthma. We also aimed to confirm the clinical utility of Th2 markers related to exacerbation. Methods: This study included 105 severe asthma patients who completed a three-year follow-up of a severe asthma cohort study, including smokers. Three Th2 markers were selected, viz., Eo, FeNO, and positive atopic status. Regarding Eo and FeNO, we determined the cutoff values for the definition of "positive" Th2 features using receiver operating characteristic curve analyses, based on the comparisons between frequent exacerbators and other patients. Results: The cutoff values for positive Th2 features were Eo >= 250 cells/mL and FeNO >= 31 ppb. Sixteen patients (15.2%) had no Th2 features, 40 (38.1%) had one, 25 ( 23.8%) had two, and 24 (22.9%) had three. A high number of positive Th2 features was significantly associated with exacerbation frequencies over three years (p < 0.05). Similarly, compared to patients with one or no Th2 features, those with three Th2 features had a significantly higher probability of having more than one exacerbation (p < 0.05). Conclusions: The cutoff values determined in the current analysis were good predictors of future exacerbations in severe asthma patients. Copyright (C) 2020, Japanese Society of Allergology. Production and hosting by Elsevier B.V. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82005 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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