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Determination of the cutoff values of Th2 markers for the prediction of future exacerbation in severe asthma: An analysis from the Hokkaido Severe Asthma Cohort Study

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Title: Determination of the cutoff values of Th2 markers for the prediction of future exacerbation in severe asthma: An analysis from the Hokkaido Severe Asthma Cohort Study
Authors: Kimura, Hirokazu Browse this author
Makita, Hironi Browse this author
Taniguchi, Natsuko Browse this author
Takei, Nozomu Browse this author
Matsumoto, Munehiro Browse this author
Kimura, Hiroki Browse this author
Goudarzi, Houman Browse this author
Shimizu, Kaoruko Browse this author
Suzuki, Masaru Browse this author
Nishimura, Masaharu Browse this author
Konno, Satoshi Browse this author →KAKEN DB
Keywords: Asthma
Cutoff value
Th2 features
Issue Date: Jan-2021
Publisher: Japanese Society of Allergology
Journal Title: Allergology international
Volume: 70
Issue: 1
Start Page: 68
End Page: 73
Publisher DOI: 10.1016/j.alit.2020.09.001
Abstract: Background: We recently reported that severe asthma patients with frequent exacerbations showed high blood eosinophil counts (Eo) and fractions of exhaled nitric oxide (FeNO) compared with non-exacerbators. However, we did not determine exact cutoff values related to exacerbation. The aim of this study was to determine the cutoff values of Eo and FeNO that could be related to the exacerbation of severe asthma. We also aimed to confirm the clinical utility of Th2 markers related to exacerbation. Methods: This study included 105 severe asthma patients who completed a three-year follow-up of a severe asthma cohort study, including smokers. Three Th2 markers were selected, viz., Eo, FeNO, and positive atopic status. Regarding Eo and FeNO, we determined the cutoff values for the definition of "positive" Th2 features using receiver operating characteristic curve analyses, based on the comparisons between frequent exacerbators and other patients. Results: The cutoff values for positive Th2 features were Eo >= 250 cells/mL and FeNO >= 31 ppb. Sixteen patients (15.2%) had no Th2 features, 40 (38.1%) had one, 25 ( 23.8%) had two, and 24 (22.9%) had three. A high number of positive Th2 features was significantly associated with exacerbation frequencies over three years (p < 0.05). Similarly, compared to patients with one or no Th2 features, those with three Th2 features had a significantly higher probability of having more than one exacerbation (p < 0.05). Conclusions: The cutoff values determined in the current analysis were good predictors of future exacerbations in severe asthma patients. Copyright (C) 2020, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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