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Immunological Responses to Seoul Orthohantavirus in Experimentally and Naturally Infected Brown Rats (Rattus norvegicus)

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Title: Immunological Responses to Seoul Orthohantavirus in Experimentally and Naturally Infected Brown Rats (Rattus norvegicus)
Authors: Yasuda, Shumpei P. Browse this author
Shimizu, Kenta Browse this author
Koma, Takaaki Browse this author
Nguyen Thuy Hoa Browse this author
Mai Quynh Le Browse this author
Wei, Zhuoxing Browse this author
Muthusinghe, Devinda S. Browse this author
Lokupathirage, Sithumini M. W. Browse this author
Hasebe, Futoshi Browse this author
Yamashiro, Tetsu Browse this author
Arikawa, Jiro Browse this author
Yoshimatsu, Kumiko Browse this author →KAKEN DB
Keywords: hemorrhagic fever with renal syndrome
Issue Date: Apr-2021
Publisher: MDPI
Journal Title: Viruses-Basel
Volume: 13
Issue: 4
Start Page: 665
Publisher DOI: 10.3390/v13040665
Abstract: To clarify the mechanism of Seoul orthohantavirus (SEOV) persistence, we compared the humoral and cell-mediated immune responses to SEOV in experimentally and naturally infected brown rats. Rats that were experimentally infected by the intraperitoneal route showed transient immunoglobulin M (IgM) production, followed by an increased anti-SEOV immunoglobulin G (IgG) antibody response and maturation of IgG avidity. The level of SEOV-specific cytotoxic T lymphocytes (CTLs) peaked at 6 days after inoculation and the viral genome disappeared from serum. In contrast, naturally infected brown rats simultaneously had a high rate of SEOV-specific IgM and IgG antibodies (28/43). Most of the IgM-positive rats (24/27) had the SEOV genome in their lungs, suggesting that chronic SEOV infection was established in those rats. In female rats with IgG avidity maturation, the viral load in the lungs was decreased. On the other hand, there was no relationship between IgG avidity and viral load in the lungs in male rats. A CTL response was not detected in naturally infected rats. The difference between immune responses in the experimentally and naturally infected rats is associated with the establishment of chronic infection in natural hosts.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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