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Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring
| Title: | Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring |
| Authors: | Miya, Aika Browse this author | | Nakamura, Akinobu Browse this author →KAKEN DB | | Handa, Takahisa Browse this author | | Nomoto, Hiroshi Browse this author | | Kameda, Hiraku Browse this author | | Cho, Kyu Yong Browse this author | | Nagai, So Browse this author | | Ito, Yoichi M. Browse this author | | Miyoshi, Hideaki Browse this author | | Atsumi, Tatsuya Browse this author |
| Issue Date: | 27-Apr-2021 |
| Publisher: | Nature Research |
| Journal Title: | Scientific reports |
| Volume: | 11 |
| Start Page: | 9057 |
| Publisher DOI: | 10.1038/s41598-021-88749-9 |
| Abstract: | The contribution of endogenous insulin secretion to glycemic variability (GV) may differ between patients with impaired insulin secretion and those with preserved secretion. Our objective was to determine the linearity of the relationship between fasting C-peptide (CPR) as a marker of endogenous insulin secretion and GV in type 2 diabetes (T2DM), regardless of the type of antidiabetic treatment. We conducted a prospective observational study using continuous glucose monitoring obtained from 284 Japanese outpatients with T2DM with various HbA1c values and antidiabetic treatment. We constructed a prediction curve of base-line CPR versus coefficient of variation (CV) and identified the clinical factors associated with CV using multiple regression analysis. Fasting CPR showed a significant negative log-linear relationship with CV (P<0.0001), and the latter being strikingly high in the low-CPR group. The multiple regression analysis showed that low CPR was an independent predictor of high CV (P<0.0001). The significant correlations were sustained in both patients with/without insulin treatment. The contribution of endogenous insulin secretion to GV depends on the extent of insulin secretion impairment. Fasting CPR may represent a useful indicator of GV instability in T2DM. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82011 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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