| Title: | Analysis of acute-phase toxicities of intensity-modulated proton therapy using a model-based approach in pharyngeal cancer patients |
| Authors: | Yasuda, Koichi Browse this author →KAKEN DB |
| Minatogawa, Hideki Browse this author |
| Dekura, Yasuhiro Browse this author |
| Takao, Seishin Browse this author |
| Tamura, Masaya Browse this author |
| Tsushima, Nayuta Browse this author |
| Suzuki, Takayoshi Browse this author |
| Kano, Satoshi Browse this author |
| Mizumachi, Takatsugu Browse this author |
| Mori, Takashi Browse this author |
| Nishioka, Kentaro Browse this author |
| Shido, Motoyasu Browse this author |
| Katoh, Norio Browse this author |
| Taguchi, Hiroshi Browse this author |
| Fujima, Noriyuki Browse this author |
| Onimaru, Rikiya Browse this author |
| Yokota, Isao Browse this author |
| Kobashi, Keiji Browse this author |
| Shimizu, Shinichi Browse this author |
| Homma, Akihiro Browse this author |
| Shirato, Hiroki Browse this author |
| Aoyama, Hidefumi Browse this author |
| Keywords: | IMPT |
| pharyngeal cancer |
| robust optimization |
| Issue Date: | Mar-2021 |
| Publisher: | Oxford University Press |
| Journal Title: | Journal of Radiation Research |
| Volume: | 62 |
| Issue: | 2 |
| Start Page: | 329 |
| End Page: | 337 |
| Publisher DOI: | 10.1093/jrr/rraa130 |
| Abstract: | Pharyngeal cancer patients treated with intensity-modulated proton therapy (IMPT) using a model-based approach were retrospectively reviewed, and acute toxicities were analyzed. From June 2016 to March 2019, 15 pharyngeal (7 naso-, 5 oro- and 3 hypo-pharyngeal) cancer patients received IMPT with robust optimization. Simulation plans for IMPT and intensity-modulated X-ray therapy (IMXT) were generated before treatment. We also reviewed 127 pharyngeal cancer patients with IMXT in the same treatment period. In the simulation planning comparison, all of the normal-tissue complication probability values for dysphagia, dysgeusia, tube-feeding dependence and xerostomia were lower for IMPT than for IMXT in the 15 patients. After completing IMPT, 13 patients completed the evaluation, and 12 of thesepatientshad a complete response. The proportions of patients who experienced grade 2 or worse acute toxicities in the IMPT and IMXT cohorts were 21.4 and 56.5% for dysphagia (P < 0.05), 46.7 and 76.3% for dysgeusia (P < 0.05), 73.3 and 62.8% for xerostomia (P = 0.43), 73.3 and 90.6% formucositis (P = 0.08) and 66.7 and 76.4% for dermatitis (P = 0.42), respectively. Multivariate analysis revealed that IMPT was independently associated with a lower rate of grade 2 or worse dysphagia and dysgeusia. After propensity score matching, 12 pairs of IMPT and IMXT patients were selected. Dysphagia was also statistically lower in IMPT than in IMXT (P < 0.05). IMPT using a model-based approach may have clinical benefits for acute dysphagia. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82137 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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