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Analysis of acute-phase toxicities of intensity-modulated proton therapy using a model-based approach in pharyngeal cancer patients

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Title: Analysis of acute-phase toxicities of intensity-modulated proton therapy using a model-based approach in pharyngeal cancer patients
Authors: Yasuda, Koichi Browse this author →KAKEN DB
Minatogawa, Hideki Browse this author
Dekura, Yasuhiro Browse this author
Takao, Seishin Browse this author
Tamura, Masaya Browse this author
Tsushima, Nayuta Browse this author
Suzuki, Takayoshi Browse this author
Kano, Satoshi Browse this author
Mizumachi, Takatsugu Browse this author
Mori, Takashi Browse this author
Nishioka, Kentaro Browse this author
Shido, Motoyasu Browse this author
Katoh, Norio Browse this author
Taguchi, Hiroshi Browse this author
Fujima, Noriyuki Browse this author
Onimaru, Rikiya Browse this author
Yokota, Isao Browse this author
Kobashi, Keiji Browse this author
Shimizu, Shinichi Browse this author
Homma, Akihiro Browse this author
Shirato, Hiroki Browse this author
Aoyama, Hidefumi Browse this author
Keywords: IMPT
pharyngeal cancer
robust optimization
Issue Date: Mar-2021
Publisher: Oxford University Press
Journal Title: Journal of Radiation Research
Volume: 62
Issue: 2
Start Page: 329
End Page: 337
Publisher DOI: 10.1093/jrr/rraa130
Abstract: Pharyngeal cancer patients treated with intensity-modulated proton therapy (IMPT) using a model-based approach were retrospectively reviewed, and acute toxicities were analyzed. From June 2016 to March 2019, 15 pharyngeal (7 naso-, 5 oro- and 3 hypo-pharyngeal) cancer patients received IMPT with robust optimization. Simulation plans for IMPT and intensity-modulated X-ray therapy (IMXT) were generated before treatment. We also reviewed 127 pharyngeal cancer patients with IMXT in the same treatment period. In the simulation planning comparison, all of the normal-tissue complication probability values for dysphagia, dysgeusia, tube-feeding dependence and xerostomia were lower for IMPT than for IMXT in the 15 patients. After completing IMPT, 13 patients completed the evaluation, and 12 of thesepatientshad a complete response. The proportions of patients who experienced grade 2 or worse acute toxicities in the IMPT and IMXT cohorts were 21.4 and 56.5% for dysphagia (P < 0.05), 46.7 and 76.3% for dysgeusia (P < 0.05), 73.3 and 62.8% for xerostomia (P = 0.43), 73.3 and 90.6% formucositis (P = 0.08) and 66.7 and 76.4% for dermatitis (P = 0.42), respectively. Multivariate analysis revealed that IMPT was independently associated with a lower rate of grade 2 or worse dysphagia and dysgeusia. After propensity score matching, 12 pairs of IMPT and IMXT patients were selected. Dysphagia was also statistically lower in IMPT than in IMXT (P < 0.05). IMPT using a model-based approach may have clinical benefits for acute dysphagia.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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