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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
One-year clinically important deterioration and long-term clinical course in Japanese patients with COPD: a multicenter observational cohort study
| Title: | One-year clinically important deterioration and long-term clinical course in Japanese patients with COPD: a multicenter observational cohort study |
| Authors: | Abe, Yuki Browse this author | | Suzuki, Masaru Browse this author | | Makita, Hironi Browse this author | | Kimura, Hirokazu Browse this author | | Shimizu, Kaoruko Browse this author | | Konno, Satoshi Browse this author | | Nishimura, Masaharu Browse this author →KAKEN DB |
| Keywords: | Chronic obstructive pulmonary disease | | Clinically important deterioration | | Composite measures | | Exacerbation | | Mortality |
| Issue Date: | 12-May-2021 |
| Publisher: | BioMed Central |
| Journal Title: | BMC Pulmonary Medicine |
| Volume: | 21 |
| Start Page: | 159 |
| Publisher DOI: | 10.1186/s12890-021-01510-w |
| Abstract: | Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with a complex progression of many clinical presentations, and clinically important deterioration (CID) has been proposed in the Western studies as a composite endpoint of disease progression. The aim of this study was to investigate the relationships between 1-year CID and the following long-term clinical outcomes in Japanese patients with COPD who have been reported to have different characteristics compared to the Westerners. Methods Among Japanese patients with COPD enrolled in the Hokkaido COPD cohort study, 259 patients who did not drop out within the first year were analyzed in this study. Two definitions of CID were used. Definition 1 comprised >= 100 mL decrease in forced expiratory volume in 1 s (FEV1), >= 4-unit increase in St George's Respiratory Questionnaire (SGRQ) score from baseline, or moderate or severe exacerbation. For Definition 2, the thresholds for the FEV1 and SGRQ score components were doubled. The presence of CID was evaluated within the first year from enrollment, and analyzed the association of the presence of CID with following 4-year risk of exacerbations and 9-year mortality. Results Patients with CID using Definition 1, but not any single CID component, during the first year had a significantly worse mortality compared with those without CID. Patients with CID using Definition 2 showed a similar trend on mortality, and had a shorter exacerbation-free survival compared with those without CID. Conclusions Adoption of CID is a beneficial and useful way for the assessment of long-term disease progression and clinical outcomes even in Japanese population with COPD. The definition of CID might be optimized according to the characteristics of COPD population and the observation period for CID. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82140 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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