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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Impact of Isolated High Home Systolic Blood Pressure and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus : A 5-Year Prospective Cohort Study
| Title: | Impact of Isolated High Home Systolic Blood Pressure and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus : A 5-Year Prospective Cohort Study |
| Authors: | Kitagawa, Nobuko Browse this author | | Kitagawa, Noriyuki Browse this author | | Ushigome, Emi Browse this author | | Ushigome, Hidetaka Browse this author | | Yokota, Isao Browse this author →KAKEN DB | | Nakanishi, Naoko Browse this author | | Hamaguchi, Masahide Browse this author | | Asano, Mai Browse this author | | Yamazaki, Masahiro Browse this author | | Fukui, Michiaki Browse this author |
| Keywords: | albuminuria | | diabetes mellitus | | isolated high home systolic blood pressure | | diabetic nephropathy |
| Issue Date: | May-2021 |
| Publisher: | MDPI |
| Journal Title: | Journal of clinical medicine |
| Volume: | 10 |
| Issue: | 9 |
| Start Page: | 1929 |
| Publisher DOI: | 10.3390/jcm10091929 |
| Abstract: | Background: A previous 2-year cohort study has shown that isolated high home systolic blood pressure (IH-HSBP) may increase the risk of diabetic nephropathy, using normal HBP as a reference. However, this association has not been previously assessed in the medium to long term. Methods: This prospective 5-year cohort study of 424 patients, with normal or mildly increased albuminuria, investigated the effect of IH-HSBP on the risk of diabetic nephropathy in patients with type 2 diabetes mellitus. Diabetic nephropathy was defined as an advancement from normal or mildly increased albuminuira to moderate or severely increased albuminuria. Results: Among 424 patients, 75 developed diabetic nephropathy during the study period. The adjusted odds ratio for developing diabetic nephropathy given IH-HSBP was 2.39 (95% confidence interval, 1.15-4.96, p = 0.02). The odds ratio for developing nephropathy in patients with IH-HSBP younger than 65 years was higher than that in patients with IH-HSBP older than 65 years. Conclusion: IH-HSBP was associated with an increased risk of diabetic nephropathy among type 2 diabetes mellitus patients with normal or mildly increased albuminuria in the medium to long term. The results support and strengthen previous reports. These findings suggest that IH-HSBP might be a useful marker in disease prognostication. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82143 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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