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Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia

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Title: Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia
Authors: Kajihara, Masahiro Browse this author
Simuunza, Martin Browse this author
Saasa, Ngonda Browse this author
Dautu, George Browse this author
Mori-Kajihara, Akina Browse this author
Qiu, Yongjin Browse this author
Nakao, Ryo Browse this author
Eto, Yoshiki Browse this author
Furumoto, Hayato Browse this author
Hang'ombe, Bernard M. Browse this author
Orba, Yasuko Browse this author
Sawa, Hirofumi Browse this author
Simulundu, Edgar Browse this author
Fukushi, Shuetsu Browse this author
Morikawa, Shigeru Browse this author
Saijo, Masayuki Browse this author
Arikawa, Jiro Browse this author
Kabilika, Swithine Browse this author
Monze, Mwaka Browse this author
Mukonka, Victor Browse this author
Mweene, Aaron Browse this author
Takada, Ayato Browse this author
Yoshimatsu, Kumiko Browse this author →KAKEN DB
Issue Date: Jun-2021
Publisher: PLOS
Journal Title: PLoS neglected tropical diseases
Volume: 15
Issue: 6
Start Page: e0009452
Publisher DOI: 10.1371/journal.pntd.0009452
Abstract: Author summary Crimean-Congo hemorrhagic fever (CCHF) is a severe viral disease mainly transmitted by ticks. Effective prophylactics and therapeutics have not been established for this disease yet. While CCHF is endemic in Africa, information on the distribution and genetic diversity of CCHF virus (CCHFV) is quite limited in many Sub-Saharan African countries. In this study, we conducted serologic and molecular epidemiologic investigations for CCHFV infection in cattle and ticks in Zambia. Serologic screening revealed that 8.4% of cattle were tested positive for CCHFV-specific IgG. Hyalomma ticks infected with CCHFV were also identified by genetic screening. Phylogenetic analyses showed that one of the CCHFVs detected in Zambia was a genetic reassortant between African and Asian CCHFV strains. Currently, Zambia is considered CCHF-free country because CCHF cases have never been reported. However, the findings in this study indicate that CCHFV is maintained in Hyalomma ticks and occasionally transmitted to vertebrate hosts such as cattle in Zambia. Further epidemiologic studies and continuous monitoring of CCHFV infection should be implemented in the southern African region. Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of CCHF in Zambia, where CCHF has never been reported, epidemiologic studies in cattle and ticks were conducted. Through an indirect immunofluorescence assay, CCHFV nucleoprotein-specific serum IgG was detected in 8.4% (88/1,047) of cattle. Among 290 Hyalomma ticks, the principal vector of CCHFV, the viral genome was detected in 11 ticks. Phylogenetic analyses of the CCHFV S and M genome segments revealed that one of the detected viruses was a genetic reassortant between African and Asian strains. This study provides compelling evidence for the presence of CCHFV in Zambia and its transmission to vertebrate hosts.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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