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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Life Science / Faculty of Advanced Life Science >
Peer-reviewed Journal Articles, etc >
Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition : the DOSANCO Health Study
| Title: | Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition : the DOSANCO Health Study |
| Authors: | Shimizu, Yu Browse this author | | Nakamura, Kiminori Browse this author | | Kikuchi, Mani Browse this author | | Ukawa, Shigekazu Browse this author | | Nakamura, Koshi Browse this author | | Okada, Emiko Browse this author | | Imae, Akihiro Browse this author | | Nakagawa, Takafumi Browse this author | | Yamamura, Ryodai Browse this author | | Tamakoshi, Akiko Browse this author | | Ayabe, Tokiyoshi Browse this author →KAKEN DB |
| Keywords: | alpha-Defensin | | Human defensin 5 | | Paneth cells | | Intestinal microbiota | | Immunosenescence | | Aging |
| Issue Date: | 20-Jul-2021 |
| Publisher: | Springer |
| Journal Title: | GeroScience |
| Volume: | 44 |
| Start Page: | 997 |
| End Page: | 1009 |
| Publisher DOI: | 10.1007/s11357-021-00398-y |
| Abstract: | intestinal microbiota composition. Fecal samples from 196 healthy Japanese (35 to 81 years old) were collected and measured HD5 concentration. HD5 concentration in the elderly group (age > 70 years old) was significantly lower than the middle-aged group (age <= 70 years old). Furthermore, individual age was negatively correlated with HD5 concentration (r = - 0.307, p < 0.001). In beta-diversity, the intestinal microbiota of the elderly showed a significantly different composition compared to the middle-aged. At the genus level, relative abundance of Collinsella, Alistipes, Peptococcaceae; unassigned, Lactobacillus, Lactococcus, Weissella,Recently, aging is considered a risk factor for various diseases. Although changes in the intestinal microbiota along with aging are thought to associate with the increased disease risk, mechanisms that cause age-related transition of the intestinal microbiota remain unknown. This study aims to clarify relationships between the amount of human defensin 5 (HD5), a Paneth cell a-defensin, which is known to regulate the intestinal microbiota, and age-related differences of the Christensenellaceae R-7 group, Megasphaera, and [Eubacterium] eligens group was significantly higher, and Lachnospiraceae; unassigned, Blautia, Anaerostipes, Fusicatenibacter, Dorea, and Faecalibacterium was significantly lower in the elderly compared to the middle-aged. In addition, HD5 concentration was negatively correlated with Alistipes, Peptococcaceae; unassigned, and Christensenellaceae R-7 group and positively correlated with Lachnospiraceae; unassigned and Dorea. These results provide novel insights into the immunosenescence of enteric innate immunity, indicating low HD5 is suggested to contribute to the agerelated differences in the intestinal microbiota and may relate to increased risk of diseases in elderly people. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82255 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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