| Title: | Immunization Coverage and Antibody Retention against Rabies in Domestic Dogs in Lusaka District, Zambia |
| Authors: | Kaneko, Chiho Browse this author |
| Sasaki, Michihito Browse this author |
| Omori, Ryosuke Browse this author |
| Nakao, Ryo Browse this author |
| Kataoka-Nakamura, Chikako Browse this author |
| Moonga, Ladslav Browse this author |
| Ndebe, Joseph Browse this author |
| Muleya, Walter Browse this author |
| Simulundu, Edgar Browse this author |
| Hang'ombe, Bernard M. Browse this author |
| Dautu, George Browse this author |
| Kajihara, Masahiro Browse this author |
| Mori-Kajihara, Akina Browse this author |
| Qiu, Yongjin Browse this author |
| Ito, Naoto Browse this author |
| Chambaro, Herman M. Browse this author |
| Sugimoto, Chihiro Browse this author |
| Higashi, Hideaki Browse this author |
| Takada, Ayato Browse this author |
| Sawa, Hirofumi Browse this author |
| Mweene, Aaron S. Browse this author |
| Isoda, Norikazu Browse this author →KAKEN DB |
| Keywords: | Africa |
| antibody titer |
| domestic dog |
| immunization coverage |
| rabies |
| Zambia |
| Issue Date: | 11-Jun-2021 |
| Publisher: | MDPI |
| Journal Title: | Pathogens |
| Volume: | 10 |
| Issue: | 6 |
| Start Page: | 738 |
| Publisher DOI: | 10.3390/pathogens10060738 |
| Abstract: | Rabies remains endemic in Zambia. Despite conducting canine vaccinations in Lusaka district, the vaccination coverage and actual seropositivity in the dog population in Lusaka district are rarely evaluated. This study estimated the seropositivity-based immunization coverage in the owned dog population in Lusaka district using the expanded program on immunization cluster survey method. The time-series trend of neutralizing antibodies against rabies in vaccinated dogs was also evaluated. Of 366 dogs in 200 dog-owning households in Lusaka district, blood samples were collected successfully from 251 dogs. In the sampled dogs, 42.2% (106/251) had an antibody titer >= 0.5 IU/mL. When the 115 dogs whose blood was not collected were assumed to be seronegative, the minimum immunization coverage in Lusaka district's owned dog population was estimated at 29.0% (95% confidence interval: 22.4-35.5). It was also found that a single vaccination with certified vaccines is capable of inducing protective levels of antibodies. In contrast, higher antibody titers were observed in multiple-vaccinated dogs than in single-vaccinated dogs, coupled with the observation of a decline in antibody titer over time. These results suggest the importance of continuous booster immunization to maintain herd immunity and provide useful information to plan mass vaccination against rabies in Zambia. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82262 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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