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Immunization Coverage and Antibody Retention against Rabies in Domestic Dogs in Lusaka District, Zambia

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Title: Immunization Coverage and Antibody Retention against Rabies in Domestic Dogs in Lusaka District, Zambia
Authors: Kaneko, Chiho Browse this author
Sasaki, Michihito Browse this author
Omori, Ryosuke Browse this author
Nakao, Ryo Browse this author
Kataoka-Nakamura, Chikako Browse this author
Moonga, Ladslav Browse this author
Ndebe, Joseph Browse this author
Muleya, Walter Browse this author
Simulundu, Edgar Browse this author
Hang'ombe, Bernard M. Browse this author
Dautu, George Browse this author
Kajihara, Masahiro Browse this author
Mori-Kajihara, Akina Browse this author
Qiu, Yongjin Browse this author
Ito, Naoto Browse this author
Chambaro, Herman M. Browse this author
Sugimoto, Chihiro Browse this author
Higashi, Hideaki Browse this author
Takada, Ayato Browse this author
Sawa, Hirofumi Browse this author
Mweene, Aaron S. Browse this author
Isoda, Norikazu Browse this author →KAKEN DB
Keywords: Africa
antibody titer
domestic dog
immunization coverage
Issue Date: 11-Jun-2021
Publisher: MDPI
Journal Title: Pathogens
Volume: 10
Issue: 6
Start Page: 738
Publisher DOI: 10.3390/pathogens10060738
Abstract: Rabies remains endemic in Zambia. Despite conducting canine vaccinations in Lusaka district, the vaccination coverage and actual seropositivity in the dog population in Lusaka district are rarely evaluated. This study estimated the seropositivity-based immunization coverage in the owned dog population in Lusaka district using the expanded program on immunization cluster survey method. The time-series trend of neutralizing antibodies against rabies in vaccinated dogs was also evaluated. Of 366 dogs in 200 dog-owning households in Lusaka district, blood samples were collected successfully from 251 dogs. In the sampled dogs, 42.2% (106/251) had an antibody titer >= 0.5 IU/mL. When the 115 dogs whose blood was not collected were assumed to be seronegative, the minimum immunization coverage in Lusaka district's owned dog population was estimated at 29.0% (95% confidence interval: 22.4-35.5). It was also found that a single vaccination with certified vaccines is capable of inducing protective levels of antibodies. In contrast, higher antibody titers were observed in multiple-vaccinated dogs than in single-vaccinated dogs, coupled with the observation of a decline in antibody titer over time. These results suggest the importance of continuous booster immunization to maintain herd immunity and provide useful information to plan mass vaccination against rabies in Zambia.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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