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Hokkaido University Collection of Scholarly and Academic Papers >
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Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology
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| Title: | Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology |
| Authors: | Fujimoto, Shinsuke Browse this author | | Torisu, Shidow Browse this author | | Kaneko, Yasuyuki Browse this author | | Mizutani, Shinya Browse this author | | Yamamoto, Shushi Browse this author | | Naganobu, Kiyokazu Browse this author | | Nakamura, Kensuke Browse this author →KAKEN DB |
| Keywords: | cholangitis | | cystic duct | | pancreatic enzyme activity in bile | | pancreatobiliary maljunction |
| Issue Date: | 22-Jul-2021 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of Veterinary Internal Medicine |
| Volume: | 35 |
| Issue: | 4 |
| Start Page: | 1780 |
| End Page: | 1788 |
| Publisher DOI: | 10.1111/jvim.16196 |
| Abstract: | Background In human medicine, congenital maljunction of the common bile duct (CBD) and main pancreatic duct (MPD), or pancreatobiliary maljunction (PBM), is a known cause of cholecystitis. Objective Pancreatic enzyme activity in the bile (a diagnostic marker for PBM) of healthy cats was measured to determine normal values and evaluate its relationship with biliary morphology. Animals Fifty-two healthy cats. Methods Cross-sectional study of the biliary tracts of healthy cats during laparoscopic ovariohysterectomy and measurement of pancreatic enzyme activity in bile. The cats were divided into groups A and B based on the ratio of the diameter of the cystic duct (CD) to the CBD. The normal ratio was 3.4. Pancreatic enzyme activity in bile was compared between the groups. Results The CBDs were straight in all cases, whereas the CDs were variably tortuous or dilated. Amylase activity in the bile (median, <100 U/L; range, <100-591 U/L) was lower than in serum in all cases, and group B, which had a CD/CBD ratio >3.4, had significantly higher amylase activity (median, 109 U/L; range, <100-591 U/L) in the bile than did group A (median, <100 U/L; range, <100-238 U/L), which had a CD/CBD ratio <3.4 (P = .0009). Conclusions and Clinical Importance The results suggest that a dilated CD is associated with reflux of pancreatic juice. In the future, it will be necessary to examine the clinical usefulness of these findings by measuring pancreatic enzyme activity in the bile of cats with cholangitis. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82320 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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