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Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived alpha-tocopherol

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Title: Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived alpha-tocopherol
Authors: Anegawa, Daisuke Browse this author
Sugiura, Yuki Browse this author
Matsuoka, Yuta Browse this author
Sone, Masamitsu Browse this author →KAKEN DB
Shichiri, Mototada Browse this author
Otsuka, Reo Browse this author
Ishida, Noriko Browse this author
Yamada, Ken-ichi Browse this author
Suematsu, Makoto Browse this author
Miura, Masayuki Browse this author
Yamaguchi, Yoshifumi Browse this author
Issue Date: 25-Jun-2021
Publisher: Nature Research
Journal Title: Communications biology
Volume: 4
Issue: 1
Start Page: 796
Publisher DOI: 10.1038/s42003-021-02297-6
Abstract: Mammalian hibernators endure severe and prolonged hypothermia that is lethal to non-hibernators, including humans and mice. The mechanisms responsible for the cold resistance remain poorly understood. Here, we found that hepatocytes from a mammalian hibernator, the Syrian hamster, exhibited remarkable resistance to prolonged cold culture, whereas murine hepatocytes underwent cold-induced cell death that fulfills the hallmarks of ferroptosis such as necrotic morphology, lipid peroxidation and prevention by an iron chelator. Unexpectedly, hepatocytes from Syrian hamsters exerted resistance to cold- and drug-induced ferroptosis in a diet-dependent manner, with the aid of their superior ability to retain dietary alpha -tocopherol (alpha T), a vitamin E analog, in the liver and blood compared with those of mice. The liver phospholipid composition is less susceptible to peroxidation in Syrian hamsters than in mice. Altogether, the cold resistance of the hibernator's liver is established by the ability to utilize alpha T effectively to prevent lipid peroxidation and ferroptosis. Daisuke Anegawa et al. investigated the mechanisms responsible for cold resistance in the Syrian hamster's hepatocytes, which exhibited remarkable resistance to prolonged cold culture. Their results suggest that hepatocytes exhibit diet-dependent resistance to cold, which is linked to the retention of alpha -tocopherol in the liver.
Type: article
Appears in Collections:低温科学研究所 (Institute of Low Temperature Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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