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Hokkaido University Collection of Scholarly and Academic Papers >
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Osteoblast-activating peptide exhibits a specific distribution pattern in mouse ovary and may regulate ovarian steroids and local calcium levels
| Title: | Osteoblast-activating peptide exhibits a specific distribution pattern in mouse ovary and may regulate ovarian steroids and local calcium levels |
| Authors: | Noreldin, Ahmed E. Browse this author | | Gewaily, Mahmoud S. Browse this author | | Saadeldin, Islam M. Browse this author | | Abomughaid, Mosleh M. Browse this author | | Khafaga, Asmaa F. Browse this author | | Elewa, Yaser H. Browse this author |
| Keywords: | Ovary | | OBAP | | estrogen | | calcium homeostasis | | immunohistochemistry |
| Issue Date: | 15-Jun-2021 |
| Publisher: | e-Century Publishing Corporation |
| Journal Title: | American journal of translational research |
| Volume: | 13 |
| Issue: | 6 |
| Start Page: | 5796 |
| End Page: | 5814 |
| PMID: | 34306327 |
| Abstract: | Osteoblast-activating peptide (OBAP) is a novel protein affecting osteoblast proliferation and differentiation, but its ovarian expression is yet to be reported. Osteoporosis is a common disease, caused mainly by low estrogen levels in females. We investigated whether OBAP regulates estrogen synthesis and osteoporosis. Using immunohistochemical analyses, we studied the distribution of OBAP in different parts of the mouse ovary. We also attempted to clarify the correlation of OBAP with ovarian steroids and calcium-regulating factors in the same ovarian tissues, including aromatase (CYP19), 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), estrogen receptor (ER), progesterone receptor (PR), receptor activator of nuclear factor-kappa B (RANK), calmodulin, calbindin, and calcium-sensing receptor. The ovarian interstitial endocrine cells (IC) showed the greatest localization of OBAP, followed by the mature corpus luteum and the oocytes of mature Graafian follicles (MGF), while there were strong negative correlations of OBAP with CYP19. Strong positive correlations with 3 beta-HSD (except MGF), RANK (except IC), and calmodulin (except MGF and IC) were demonstrated. OBAP also showed partially positive correlations with ER and PR in the corpus luteum and with IC and calbindin in the MGF. We conclude that OBAP might be related to estrogen synthesis and calcium homeostasis. |
| Publisher URI: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290782/ |
| Relation: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290782/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82396 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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