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12 alpha-Hydroxylated bile acid enhances accumulation of adiponectin and immunoglobulin A in the rat ileum

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Title: 12 alpha-Hydroxylated bile acid enhances accumulation of adiponectin and immunoglobulin A in the rat ileum
Authors: Yoshitsugu, Reika Browse this author
Liu, Hongxia Browse this author
Kamo, Yoshie Browse this author
Takeuchi, Akari Browse this author
Joe, Ga-Hyun Browse this author
Tada, Koji Browse this author
Kikuchi, Keidai Browse this author
Fujii, Nobuyuki Browse this author
Kitta, Shinri Browse this author
Hori, Shota Browse this author
Takatsuki, Manami Browse this author
Iwaya, Hitoshi Browse this author
Tanaka, Yasutake Browse this author
Shimizu, Hidehisa Browse this author
Ishizuka, Satoshi Browse this author →KAKEN DB
Issue Date: 21-Jun-2021
Publisher: Nature Research
Journal Title: Scientific reports
Volume: 11
Issue: 1
Start Page: 12939
Publisher DOI: 10.1038/s41598-021-92302-z
Abstract: We previously reported that dietary supplementation with cholic acid (CA), the primary 12 alpha -hydroxylated (12 alpha OH) bile acid (BA), reduces plasma adiponectin concentration in rats. The aim of this study was to examine the distribution of adiponectin in the body of CA-fed rats and its influence on mucosal immunoglobulin A concentration in the intestine. Rats were fed a diet supplemented with or without CA (0.5 g CA/kg diet) for 13 weeks. A reduction in plasma adiponectin level was observed from week 3. At the end of the experiment, the CA diet reduced plasma adiponectin concentration both in the portal and aortic plasma. Accumulation of adiponectin was accompanied by an increase in cadherin-13 mRNA expression in the ileal mucosa of CA-fed rats. No increase was observed in adiponectin mRNA expression in the ileal and adipose tissues of the CA-fed rats. Immunoglobulin A concentration in the ileal mucosa was elevated in the CA-fed rats and was correlated with the ileal adiponectin concentration. 12 alpha OH BAs may modulate mucosal immune response that are involved in the accumulation of adiponectin in the ileum.
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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