Title: | 12 alpha-Hydroxylated bile acid enhances accumulation of adiponectin and immunoglobulin A in the rat ileum |
Authors: | Yoshitsugu, Reika Browse this author |
Liu, Hongxia Browse this author |
Kamo, Yoshie Browse this author |
Takeuchi, Akari Browse this author |
Joe, Ga-Hyun Browse this author |
Tada, Koji Browse this author |
Kikuchi, Keidai Browse this author |
Fujii, Nobuyuki Browse this author |
Kitta, Shinri Browse this author |
Hori, Shota Browse this author |
Takatsuki, Manami Browse this author |
Iwaya, Hitoshi Browse this author |
Tanaka, Yasutake Browse this author |
Shimizu, Hidehisa Browse this author |
Ishizuka, Satoshi Browse this author →KAKEN DB |
Issue Date: | 21-Jun-2021 |
Publisher: | Nature Research |
Journal Title: | Scientific reports |
Volume: | 11 |
Issue: | 1 |
Start Page: | 12939 |
Publisher DOI: | 10.1038/s41598-021-92302-z |
Abstract: | We previously reported that dietary supplementation with cholic acid (CA), the primary 12 alpha -hydroxylated (12 alpha OH) bile acid (BA), reduces plasma adiponectin concentration in rats. The aim of this study was to examine the distribution of adiponectin in the body of CA-fed rats and its influence on mucosal immunoglobulin A concentration in the intestine. Rats were fed a diet supplemented with or without CA (0.5 g CA/kg diet) for 13 weeks. A reduction in plasma adiponectin level was observed from week 3. At the end of the experiment, the CA diet reduced plasma adiponectin concentration both in the portal and aortic plasma. Accumulation of adiponectin was accompanied by an increase in cadherin-13 mRNA expression in the ileal mucosa of CA-fed rats. No increase was observed in adiponectin mRNA expression in the ileal and adipose tissues of the CA-fed rats. Immunoglobulin A concentration in the ileal mucosa was elevated in the CA-fed rats and was correlated with the ileal adiponectin concentration. 12 alpha OH BAs may modulate mucosal immune response that are involved in the accumulation of adiponectin in the ileum. |
Rights: | http://creativecommons.org/licenses/by/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/82443 |
Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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