| Title: | Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect |
| Authors: | Lou, Jenny Browse this author |
| Aragaki, Masato Browse this author →KAKEN DB |
| Bernards, Nicholas Browse this author |
| Kinoshita, Tomonari Browse this author |
| Mo, Jessica Browse this author |
| Motooka, Yamoto Browse this author |
| Ishiwata, Tsukasa Browse this author |
| Gregor, Alexander Browse this author |
| Chee, Tess Browse this author |
| Chen, Zhenchian Browse this author |
| Chen, Juan Browse this author |
| Kaga, Kichizo Browse this author |
| Wakasa, Satoru Browse this author |
| Zheng, Gang Browse this author |
| Yasufuku, Kazuhiro Browse this author |
| Keywords: | immune response |
| immunotherapy |
| PD-1 |
| photodynamic therapy |
| porphyrin |
| thoracic malignant tumor |
| Issue Date: | 2-Aug-2021 |
| Journal Title: | Nanophotonics |
| Volume: | 10 |
| Issue: | 12 |
| Start Page: | 3279 |
| End Page: | 3294 |
| Publisher DOI: | 10.1515/nanoph-2021-0241 |
| Abstract: | While photodynamic therapy (PDT) can induce acute inflammation in the irradiated tumor site, a sustained systemic, adaptive immune response is desirable, as it may control the growth of nonirradiated distant disease. Previously, we developed porphyrin lipoprotein (PLP), a ∼20 nm nanoparticle photosensitizer, and observed that it not only efficiently eradicated irradiated primary VX2 buccal carcinomas in rabbits, but also induced regression of nonirradiated metastases in a draining lymph node. We hypothesized that PLP-mediated PDT can induce an abscopal effect and we sought to investigate the immune mechanism underlying such a response in a highly aggressive, dual subcutaneous AE17-OVA+ mesothelioma model in C57BL/6 mice. Four cycles of PLP-mediated PDT was sufficient to delay the growth of a distal, nonirradiated tumor four-fold relative to controls. Serum cytokine analysis revealed high interleukin-6 levels, showing a 30-fold increase relative to phosphate-buffered solution (PBS) treated mice. Flow cytometry revealed an increase in CD4+ T cells and effector memory CD8+ T cells in non-irradiated tumors. Notably, PDT in combination with PD-1 antibody therapy prolonged survival compared to monotherapy and PBS. PLP-mediated PDT shows promise in generating a systemic immune response that can complement other treatments, improving prognoses for patients with metastatic cancers. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82445 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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