HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
International Institute for Zoonosis Control >
Peer-reviewed Journal Articles, etc >

Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia
Authors: Changula, Katendi Browse this author
Simulundu, Edgar Browse this author
Lombe, Boniface Pongombo Browse this author
Nakayama, Eri Browse this author
Miyamoto, Hiroko Browse this author
Takahashi, Yuji Browse this author
Sawa, Hirofumi Browse this author →KAKEN DB
Simukonda, Chuma Browse this author
Hang'ombe, Bernard M. Browse this author
Takada, Ayato Browse this author →KAKEN DB
Keywords: Ebola virus
Marburg virus
nonhuman primate
Issue Date: Jul-2021
Publisher: MDPI
Journal Title: Viruses-Basel
Volume: 13
Issue: 7
Start Page: 1283
Publisher DOI: 10.3390/v13071283
Abstract: Ebolaviruses and marburgviruses are filoviruses that are known to cause severe hemorrhagic fever in humans and nonhuman primates (NHPs). While some bat species are suspected to be natural reservoirs of these filoviruses, wild NHPs often act as intermediate hosts for viral transmission to humans. Using an enzyme-linked immunosorbent assay, we screened two NHP species, wild baboons and vervet monkeys captured in Zambia, for their serum IgG antibodies specific to the envelope glycoproteins of filoviruses. From 243 samples tested, 39 NHPs (16%) were found to be seropositive either for ebolaviruses or marburgviruses with endpoint antibody titers ranging from 100 to 25,600. Interestingly, antibodies reactive to Reston virus, which is found only in Asia, were detected in both NHP species. There was a significant difference in the seropositivity for the marburgvirus antigen between the two NHP species, with baboons having a higher positive rate. These results suggest that wild NHPs in Zambia might be nonlethally exposed to these filoviruses, and this emphasizes the need for continuous monitoring of filovirus infection in wild animals to better understand the ecology of filoviruses and to assess potential risks of outbreaks in humans in previously nonendemic countries.
Type: article
Appears in Collections:人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University