| Title: | Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients |
| Authors: | Wada, Takeshi Browse this author →KAKEN DB |
| Shiraishi, Atsushi Browse this author |
| Gando, Satoshi Browse this author |
| Yamakawa, Kazuma Browse this author |
| Fujishima, Seitaro Browse this author |
| Saitoh, Daizoh Browse this author |
| Kushimoto, Shigeki Browse this author |
| Ogura, Hiroshi Browse this author |
| Abe, Toshikazu Browse this author |
| Mayumi, Toshihiko Browse this author |
| Sasaki, Junichi Browse this author |
| Kotani, Joji Browse this author |
| Takeyama, Naoshi Browse this author |
| Tsuruta, Ryosuke Browse this author |
| Takuma, Kiyotsugu Browse this author |
| Yamashita, Norio Browse this author |
| Shiraishi, Shin-ichiro Browse this author |
| Ikeda, Hiroto Browse this author |
| Shiino, Yasukazu Browse this author |
| Tarui, Takehiko Browse this author |
| Nakada, Taka-aki Browse this author |
| Hifumi, Toru Browse this author |
| Okamoto, Kohji Browse this author |
| Sakamoto, Yuichiro Browse this author |
| Hagiwara, Akiyoshi Browse this author |
| Masuno, Tomohiko Browse this author |
| Ueyama, Masashi Browse this author |
| Fujimi, Satoshi Browse this author |
| Umemura, Yutaka Browse this author |
| Otomo, Yasuhiro Browse this author |
| Issue Date: | 26-May-2021 |
| Publisher: | Nature Research |
| Journal Title: | Scientific reports |
| Volume: | 11 |
| Issue: | 1 |
| Start Page: | 11031 |
| Publisher DOI: | 10.1038/s41598-021-90492-0 |
| Abstract: | Trauma patients die from massive bleeding due to disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype in the early phase, which transforms to DIC with a thrombotic phenotype in the late phase of trauma, contributing to the development of multiple organ dysfunction syndrome (MODS) and a consequently poor outcome. This is a sub-analysis of a multicenter prospective descriptive cross-sectional study on DIC to evaluate the effect of a DIC diagnosis on the survival probability and predictive performance of DIC scores for massive transfusion, MODS, and hospital death in severely injured trauma patients. A DIC diagnosis on admission was associated with a lower survival probability (Log Rank P<0.001), higher frequency of massive transfusion and MODS and a higher mortality rate than no such diagnosis. The DIC scores at 0 and 3 h significantly predicted massive transfusion, MODS, and hospital death. Markers of thrombin and plasmin generation and fibrinolysis inhibition also showed a good predictive ability for these three items. In conclusion, a DIC diagnosis on admission was associated with a low survival probability. DIC scores obtained immediately after trauma predicted a poor prognosis of severely injured trauma patients. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82524 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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