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Hokkaido University Collection of Scholarly and Academic Papers >
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Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study
| Title: | Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study |
| Authors: | Kobayashi, Sumitaka Browse this author →KAKEN DB | | Sata, Fumihiro Browse this author | | Goudarzi, Houman Browse this author | | Araki, Atsuko Browse this author | | Miyashita, Chihiro Browse this author | | Sasaki, Seiko Browse this author | | Okada, Emiko Browse this author | | Iwasaki, Yusuke Browse this author | | Nakajima, Tamie Browse this author | | Kishi, Reiko Browse this author →KAKEN DB |
| Issue Date: | 11-May-2021 |
| Publisher: | Nature Research |
| Journal Title: | Scientific reports |
| Volume: | 11 |
| Issue: | 1 |
| Start Page: | 9994 |
| Publisher DOI: | 10.1038/s41598-021-89285-2 |
| Abstract: | The effect of interactions between perfluorooctanesulfonic (PFOS)/perfluorooctanoic acid (PFOA) levels and nuclear receptor genotypes on fatty acid (FA) levels, including those of triglycerides, is not clear understood. Therefore, in the present study, we aimed to analyse the association of PFOS/PFOA levels and single-nucleotide polymorphisms (SNPs) in nuclear receptors with FA levels in pregnant women. We analysed 504 mothers in a birth cohort between 2002 and 2005 in Japan. Serum PFOS/PFOA and FA levels were measured using liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Maternal genotypes in PPARA (rs1800234; rs135561), PPARG (rs3856806), PPARGC1A (rs2970847; rs8192678), PPARD (rs1053049; rs2267668), CAR (rs2307424; rs2501873), LXRA (rs2279238) and LXRB (rs1405655; rs2303044; rs4802703) were analysed. When gene-environment interaction was considered, PFOS exposure (log(10) scale) decreased palmitic, palmitoleic, and oleic acid levels (log(10) scale), with the observed beta in the range of - 0.452 to - 0.244; PPARGC1A (rs8192678) and PPARD (rs1053049; rs2267668) genotypes decreased triglyceride, palmitic, palmitoleic, and oleic acid levels, with the observed beta in the range of - 0.266 to - 0.176. Interactions between PFOS exposure and SNPs were significant for palmitic acid (P-int=0.004 to 0.017). In conclusion, the interactions between maternal PFOS levels and PPARGC1A or PPARD may modify maternal FA levels. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82525 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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