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A balance between antagonizing PAR proteins specifies the pattern of asymmetric and symmetric divisions in C. elegans embryogenesis
| Title: | A balance between antagonizing PAR proteins specifies the pattern of asymmetric and symmetric divisions in C. elegans embryogenesis |
| Authors: | Lim, Yen Wei Browse this author | | Wen, Fu-Lai Browse this author | | Shankar, Prabhat Browse this author | | Shibata, Tatsuo Browse this author | | Motegi, Fumio Browse this author →KAKEN DB |
| Issue Date: | 6-Jul-2021 |
| Publisher: | Cell Press |
| Journal Title: | Cell Reports |
| Volume: | 36 |
| Issue: | 1 |
| Start Page: | 109326 |
| Publisher DOI: | 10.1016/j.celrep.2021.109326 |
| Abstract: | Coordination between cell differentiation and proliferation during development requires the balance between asymmetric and symmetric modes of cell division. However, the cellular intrinsic cue underlying the choice between these two division modes remains elusive. Here, we show evidence in Caenorhabditis elegans that the invariable lineage of the division modes is specified by the balance between antagonizing complexes of partitioning-defective (PAR) proteins. By uncoupling unequal inheritance of PAR proteins from that of fate determinants during cell division, we demonstrate that changes in the balance between PAR-2 and PAR-6 can be sufficient to re-program the division modes from symmetric to asymmetric and vice versa in two daughter cells. The division mode adopted occurs independently of asymmetry in cytoplasmic fate determinants, cell-size asymmetry, and cell-cycle asynchrony between sister cells. We propose that the balance between PAR proteins represents an intrinsic self-organizing cue for the specification of the two division modes during development. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82527 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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