HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Blood flow dynamics with four-dimensional flow cardiovascular magnetic resonance in patients with aortic stenosis before and after transcatheter aortic valve replacement

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Blood flow dynamics with four-dimensional flow cardiovascular magnetic resonance in patients with aortic stenosis before and after transcatheter aortic valve replacement
Authors: Komoriyama, Hirokazu Browse this author
Kamiya, Kiwamu Browse this author
Nagai, Toshiyuki Browse this author →KAKEN DB
Oyama-Manabe, Noriko Browse this author
Tsuneta, Satonori Browse this author
Kobayashi, Yuta Browse this author
Kato, Yoshiya Browse this author
Sarashina, Miwa Browse this author
Omote, Kazunori Browse this author
Konishi, Takao Browse this author
Sato, Takuma Browse this author
Tsujinaga, Shingo Browse this author
Iwano, Hiroyuki Browse this author
Shingu, Yasushige Browse this author
Wakasa, Satoru Browse this author
Anzai, Toshihisa Browse this author →KAKEN DB
Keywords: Four-dimensional flow cardiovascular magnetic resonance
Aortic stenosis
Transcatheter aortic valve replacement
Blood flow dynamics
Issue Date: 28-Jun-2021
Publisher: BioMed Central
Journal Title: Journal of Cardiovascular Magnetic Resonance
Volume: 23
Issue: 1
Start Page: 81
Publisher DOI: 10.1186/s12968-021-00771-y
Abstract: Background Pre- and post-procedural hemodynamic changes which could affect adverse outcomes in aortic stenosis (AS) patients who undergo transcatheter aortic valve replacement (TAVR) have not been well investigated. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) enables accurate analysis of blood flow dynamics such as flow velocity, flow pattern, wall shear stress (WSS), and energy loss (EL). We sought to examine the changes in blood flow dynamics of patients with severe AS who underwent TAVR. Methods We examined 32 consecutive severe AS patients who underwent TAVR between May 2018 and June 2019 (17 men, 82 +/- 5 years, median left ventricular ejection fraction 61%, 6 self-expanding valve), after excluding those without CMR because of a contraindication or inadequate imaging from the analyses. We analyzed blood flow patterns, WSS and EL in the ascending aorta (AAo), and those changes before and after TAVR using 4D flow CMR. Results After TAVR, semi-quantified helical flow in the AAo was significantly decreased (1.4 +/- 0.6 vs. 1.9 +/- 0.8, P = 0.002), whereas vortical flow and eccentricity showed no significant changes. WSS along the ascending aortic circumference was significantly decreased in the left (P = 0.038) and left anterior (P = 0.033) wall at the basal level, right posterior (P = 0.011) and left (P = 0.010) wall at the middle level, and right (P = 0.012), left posterior (P = 0.019) and left anterior (P = 0.028) wall at the upper level. EL in the AAo was significantly decreased (15.6 [10.8-25.1 vs. 25.8 [18.6-36.2]] mW, P = 0.012). Furthermore, a significant negative correlation was observed between EL and effective orifice area index after TAVR (r = - 0.38, P = 0.034). Conclusions In severe AS patients undergoing TAVR, 4D flow CMR demonstrates that TAVR improves blood flow dynamics, especially when a larger effective orifice area index is obtained.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University