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Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients

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Title: Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients
Authors: Yokota, Takashi Browse this author →KAKEN DB
Kinugawa, Shintaro Browse this author
Hirabayashi, Kagami Browse this author
Yamato, Mayumi Browse this author
Takada, Shingo Browse this author
Suga, Tadashi Browse this author
Nakano, Ippei Browse this author
Fukushima, Arata Browse this author
Matsushima, Shouji Browse this author
Okita, Koichi Browse this author
Tsutsui, Hiroyuki Browse this author
Issue Date: 26-Jan-2021
Publisher: Nature Research
Journal Title: Scientific reports
Volume: 11
Start Page: 2272
Publisher DOI: 10.1038/s41598-021-81736-0
Abstract: Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood testing, cardiopulmonary exercise testing, and magnetic resonance spectroscopy (MRS). The serum thiobarbituric acid reactive substances (TBARS; lipid peroxides) were significantly higher (5.1 +/- 1.1 vs. 3.4 +/- 0.7 mu mol/L, p<0.01) and the serum activities of superoxide dismutase (SOD), an antioxidant, were significantly lower (9.2<plus/minus>7.1 vs. 29.4 +/- 9.7 units/L, p<0.01) in the CHF cohort versus the controls. The oxygen uptake (VO2) at both peak exercise and anaerobic threshold was significantly depressed in the CHF patients; the parameters of aerobic capacity were inversely correlated with serum TBARS and positively correlated with serum SOD activity. The phosphocreatine loss during plantar-flexion exercise and intramyocellular lipid content in the participants' leg muscle measured by (31)phosphorus- and (1)proton-MRS, respectively, were significantly elevated in the CHF patients, indicating abnormal intramuscular energy metabolism. Notably, the skeletal muscle abnormalities were related to the enhanced systemic oxidative stress. Our analyses revealed that systemic oxidative stress is related to lowered whole-body aerobic capacity and skeletal muscle dysfunction in CHF patients.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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